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Type: Journal article
Title: RNA in cancer
Author: Goodall, G.J.
Wickramasinghe, V.O.
Citation: Nature Reviews Cancer, 2021; 21(1):22-36
Publisher: Springer Nature
Issue Date: 2021
ISSN: 1474-175X
Statement of
Gregory J. Goodall and Vihandha O. Wickramasinghe
Abstract: While the processing of mRNA is essential for gene expression, recent findings have highlighted that RNA processing is systematically altered in cancer. Mutations in RNA splicing factor genes and the shortening of 3' untranslated regions are widely observed. Moreover, evidence is accumulating that other types of RNAs, including circular RNAs, can contribute to tumorigenesis. In this Review, we highlight how altered processing or activity of coding and non-coding RNAs contributes to cancer. We introduce the regulation of gene expression by coding and non-coding RNA and discuss both established roles (microRNAs and long non-coding RNAs) and emerging roles (selective mRNA processing and circular RNAs) for RNAs, highlighting the potential mechanisms by which these RNA subtypes contribute to cancer. The widespread alteration of coding and non-coding RNA demonstrates that altered RNA biogenesis contributes to multiple hallmarks of cancer.
Keywords: RNA processing
Rights: © Crown 2020
DOI: 10.1038/s41568-020-00306-0
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