Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/130193
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Type: Journal article
Title: Childhood infections, vaccinations, and tonsillectomy and risk of first clinical diagnosis of CNS demyelination in the Ausimmune Study
Author: Hughes, A.M.
Ponsonby, A.L.
Dear, K.
Dwyer, T.
Taylor, B.V.
van der Mei, I.
Valery, P.C.
Lucas, R.M.
Citation: Multiple Sclerosis and Related Disorders, 2020; 42:1-8
Publisher: Elsevier
Issue Date: 2020
ISSN: 2211-0348
2211-0356
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Responsibility: 
A.M.Hughes, A.-L.Ponsonby, K.Dear, T.Dwyer, B.V.Taylor, I.van der Mei ... et al.
Abstract: Background: The association between childhood vaccinations and infections and risk of multiple sclerosis is unclear; few studies have considered age at vaccination/infection. Objective: To explore age-related associations between childhood vaccinations, infection and tonsillectomy and risk of a first clinical diagnosis of CNS demyelination. Methods: Data on case (n = 275, 76.6% female; mean age 38.6 years) and age- and sex-matched control (n = 529) participants in an incident population-based case-control study included self-reported age at time of childhood vaccinations, infections, and tonsillectomy. Conditional logistic regression models were used to calculate adjusted odds ratios (AOR) and 95% confidence intervals (CI). Results: Poliomyelitis vaccination prior to school-age was associated with increased risk of a first clinical diagnosis of CNS demyelination (AOR = 2.60, 95%CI 1.02–6.68), based on a very small unvaccinated reference group. Late (11–15 years) rubella vaccination (compared to none) was associated with lower odds of being a case (AOR = 0.47, 95%CI 0.27–0.83). Past infectious mononucleosis at 11–15 years (AOR = 2.84, 95%CI 1.0–7.57) and 16–20 years (AOR = 1.92, 95%CI 1.12–3.27) or tonsillectomy in adolescence (11–15 years: AOR = 2.45, 95%CI 1.12–5.35), including after adjustment for IM, were associated with increased risk of a first clinical diagnosis of CNS demyelination. Conclusions: Age at vaccination, infection or tonsillectomy may alter the risk of subsequent CNS demyelination. Failing to account for age effects may explain inconsistencies in past findings.
Keywords: Multiple sclerosis; infections; vaccinations; tonsillectomy; case-control study; demyelination
Rights: © 2020 Elsevier B.V. All rights reserved.
DOI: 10.1016/j.msard.2020.102062
Grant ID: http://purl.org/au-research/grants/nhmrc/1083090
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