Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/130297
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Type: Journal article
Title: Insulin resistance is associated with significant clinical atherosclerosis in nondiabetic patients with acute myocardial infarction
Author: Karrowni, W.
Li, Y.
Jones, P.G.
Cresci, S.
Abdallah, M.S.
Lanfear, D.E.
Maddox, T.M.
McGuire, D.K.
Spertus, J.A.
Horwitz, P.A.
Citation: Arteriosclerosis, Thrombosis and Vascular Biology, 2013; 33(9):2245-2251
Publisher: Lippincott Williams & Wilkins
Issue Date: 2013
ISSN: 1079-5642
1524-4636
Statement of
Responsibility: 
Wassef Karrowni, Yan Li, Philip G. Jones, Sharon Cresci, Mouin S. Abdallah ... John A. Spertus ... et al.
Abstract: The prevalence of insulin resistance (IR) is increasing worldwide because of increasing age, obesity, and physical inactivity. Emerging evidence supports a direct proatherogenic effect of IR on the coronary vasculature, but the relation between IR and angiographic atherosclerosis in a real-world clinical setting is uncertain. In this work, we assessed whether IR is independently associated with clinically significant angiographic atherosclerosis in nondiabetic individuals.We examined the association between IR and the extent of coronary atherosclerosis determined by angiography in 1073 nondiabetic patients surviving acute myocardial infarction. Patients were divided into quartiles on the basis of the homeostasis model assessment grading of IR, and associations between IR and multivessel coronary artery disease, defined as ≥ 2 arteries with ≥ 70% stenosis (or ≥ 50% left main stenosis), were analyzed in bivariate and multivariable modeling. Overall, the cohort had a median age of 56 years; 28.9% women and 21.8% nonwhite. The crude prevalence of multivessel coronary artery disease was 37.8%, 42.3%, 47.2%, and 48.0% for homeostasis model assessment grading of IR quartiles 1, 2, 3, and 4, respectively (P(trend) = 0.009). In multivariable modeling, compared with quartile 1, both quartile 3 (relative risk [95% confidence interval], 1.31 [1.07-1.60]) and quartile 4 (1.29 [1.03-1.60]) were independently associated with multivessel coronary artery disease. Covariates in the model included patient demographic and clinical characteristics and metabolic factors (low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, triglyceride, glycosylated hemoglobin, and high-sensitivity C-reactive protein).We demonstrate an independent association between IR and multivessel coronary artery disease in nondiabetic postmyocardial infarction patients. Our findings strengthen the experimental evidence for a direct atherogenic effect of IR independent of glucose control and other components of the metabolic syndrome.
Keywords: Biomarkers
DOI: 10.1161/ATVBAHA.113.301585
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