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Type: Journal article
Title: Daily activities are associated with non-invasive measures of neuroplasticity in older adults
Author: Smith, A.E.
Dumuid, D.
Goldsworthy, M.R.
Graetz, L.
Hodyl, N.
Thornton, N.L.R.
Ridding, M.C.
Citation: Clinical Neurophysiology, 2021; 132(4):984-992
Publisher: Elsevier BV
Issue Date: 2021
ISSN: 1388-2457
Statement of
Ashleigh E.Smith, Dorothea Dumuid, Mitchell R.Goldsworthy, Lynton Graetz, Nicolette Hodyl, Nicollette L.R.Thornton, Michael C.Ridding
Abstract: Objective We aimed to determine the association between daily activities (sleep, sedentary behavior and physical activities) and neuroplasticity in older adults by measuring motor evoked potential amplitudes (MEPs) elicited after a single and spaced continuous theta burst stimulation (cTBS) paradigm, targeting the primary motor cortex. Methods MEPs were recorded from the right first dorsal interosseous muscle of 34 older adults (66.9 ± 4.5 years) by delivering single-pulse TMS before, between and at 0, 10, 20, 40 and 60 min after the application of spaced-cTBS separated by 10 min. Habitual activity was assessed by accelerometry for 24 h/day over 7-days. Multiple linear regression models determined if the time-use composition (sleep, sedentary behavior and physical activities) was associated with neuroplasticity response. Results More physical activity at the equal expense of sleep and sedentary behaviors was associated with greater motor cortical neuroplasticity. Associations appeared to be driven by more time spent in light- but not moderate-to-vigorous- physical activities. Conclusions Engaging in light physical activity at the expense of sleep and sedentary behavior was associated with greater LTD-like motor cortex neuroplasticity (as measured with cTBS) in older adults. Significance These findings suggest the promotion of physical activity among older adults to support brain neuroplasticity.
Keywords: Transcranial magnetic stimulation (TMS); Compositional data analysis (CoDA); Neuroplasticity; Physical activity (PA); Sleep Sedentary behavior (SB)
Rights: © 2021 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.
DOI: 10.1016/j.clinph.2021.01.016
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