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Type: Journal article
Title: Injectable gelatin microspheres loaded with platelet rich plasma improve wound healing by regulating early inflammation
Author: Zhou, S.
Li, L.
Chen, C.
Chen, Y.
Zhou, L.
Zhou, F.H.
Dong, J.
Wang, L.
Citation: International Journal of Medical Sciences, 2021; 18(9):1910-1920
Publisher: Ivyspring International Publisher
Issue Date: 2021
ISSN: 1449-1907
Statement of
Shaolong Zhou, Li Li, Chen Chen, Yi Chen, Linhua Zhou, Fiona H. Zhou Jianghui Dong, Liping Wang
Abstract: We investigated the potential of gelatin microspheres (GMs) loaded with platelet-rich plasma (PRP) to enhance their wound healing effect. Platelets from the PRP were immobilized onto GMs to form biomimetic bioreactor GM+PRP. The therapeutic effect of this agent was further investigated in vivo on a wound-healing model in rats. Wounds were locally injected with phosphate buffered saline (PBS), GM, PRP, and GM+PRP. Wound healing rate, vessel density, and inflammation level were measured histologically, by RT-PCR, and by Western blotting at days 3, 7, 14, and 21. Platelets on GM caused a continuous high release in both interleukin-10 and metalloproteinase-3 compared with PRP alone. Both GM+PRP and PRP successfully accelerated the wound healing process, while GM alone did not improve the wound healing process compared with the untreated control. Wounds treated with GM+PRP resulted in shorter healing period and improved dermal structure. GM+PRP improved angiogenesis in the wound by increasing expression of angiogenic factors. GM+PRP prolonged and enhanced the cytokine release profile compared with PRP. By promoting the inflammatory and angiogenic responses, GM+PRP has the potential to improve wound healing. Our findings demonstrate that GMs are an injectable carrier that enhanced the therapeutic effects of PRP.
Keywords: Platelet-rich plasma; gelatin microspheres; early inflammation; wound healing; tissue regeneration
Rights: This is an open access article distributed under the terms of the Creative Commons Attribution License ( See for full terms and conditions.
DOI: 10.7150/ijms.51060
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