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Type: Journal article
Title: Role of bile acids in the regulation of food intake, and their dysregulation in metabolic disease
Author: Xie, C.
Huang, W.
Young, R.L.
Jones, K.L.
Horowitz, M.
Rayner, C.K.
Wu, T.
Citation: Nutrients, 2021; 13(4):1-16
Publisher: MDPI
Issue Date: 2021
ISSN: 2072-6643
Statement of
Cong Xie, Weikun Huang, Richard L. Young, Karen L. Jones, Michael Horowitz, Christopher K. Rayner and Tongzhi Wu
Abstract: Bile acids are cholesterol-derived metabolites with a well-established role in the digestion and absorption of dietary fat. More recently, the discovery of bile acids as natural ligands for the nuclear farnesoid X receptor (FXR) and membrane Takeda G-protein-coupled receptor 5 (TGR5), and the recognition of the effects of FXR and TGR5 signaling have led to a paradigm shift in knowledge regarding bile acid physiology and metabolic health. Bile acids are now recognized as signaling molecules that orchestrate blood glucose, lipid and energy metabolism. Changes in FXR and/or TGR5 signaling modulates the secretion of gastrointestinal hormones including glucagon-like peptide-1 (GLP-1) and peptide YY (PYY), hepatic gluconeogenesis, glycogen synthesis, energy expenditure, and the composition of the gut microbiome. These effects may contribute to the metabolic benefits of bile acid sequestrants, metformin, and bariatric surgery. This review focuses on the role of bile acids in energy intake and body weight, particularly their effects on gastrointestinal hormone secretion, the changes in obesity and T2D, and their potential relevance to the management of metabolic disorders.
Keywords: Bile acids; TGR-5; FXR; gastrointestinal hormones; energy intake; body weight; obesity; type 2 diabetes
Rights: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// 4.0/). This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
RMID: 1000039496
DOI: 10.3390/nu13041104
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Appears in Collections:Medicine publications

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