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Type: Journal article
Title: Moderator role of vitamin D concentrations on the association between metabolic syndrome and C-reactive protein among adults
Author: Fassula, A.S.
Gonzalez-Chica, D.
Giehl, M.C.
Silva, D.A.S.
Cembranel, F.
Moreno, Y.M.F.
Citation: Archives of Endocrinology and Metabolism, 2020; 64(6):695-703
Publisher: Brazilian Society of Endocrinology and Metabolism
Issue Date: 2020
ISSN: 2359-3997
Statement of
Angelica Scherlowski Fassula, David Gonzalez-Chica, Marui Corseuil Giehl, Diego Augusto Santos Silva, Francieli Cembranel, Yara Maria Franco Moreno
Abstract: OBJECTIVE:To evaluate the association between MetS, its components and insulin resistance (IR) with 25(OH)D and hsCRP. The moderator role of 25(OH)D in the association of MetS, its diagnostic components and IR with hsCRP were also explored. MATERIALS AND METHODS:A cross-sectional study (2014/2015) with a population-based cohort in Southern Brazil (n = 605). Metabolic syndrome (MetS) diagnosis was defined based on the Joint Interim Statement, while the Homeostasis Model Assessment of insulin resistance (IR) (HOMA-IR) was used for determining IR. Serum concentrations of 25-hydroxy vitamin D [25(OH)D] (ng/mL) and high sensitivity C-reactive protein (hsCRP) (mg/L) were evaluated following standard protocols. 25(OH)D was categorized as sufficiency (>30 ng/mL), insufficiency (20-30 ng/mL) or deficiency (<20 ng/mL) to test its moderator role. Multiple linear regression was used to test the associations. The results were adjusted for possible confounders. RESULTS AND DISCUSSION:Hypertriglyceridemia and IR were associated with lower 25(OH)D concentrations. However, except for systolic blood pressure, other MetS components and IR were associated with higher hsCRP. The association between elevated waist circumference (WC) and hsCRP was moderated by the 25(OH)D concentrations. The hsCRP median concentrations were more than two times higher among those with elevated WC and 25(OH)D insufficiency or deficiency. In this study, inadequate concentrations of 25(OH)D increased the adverse relationship between elevated WC and inflammation. 25(OH)D concentrations could be incorporated into the clinical protocols for monitoring individuals with abdominal obesity to identify those at a higher risk of complications.
Keywords: Metabolic syndrome; vitamin D; C-reactive protein; insulin resistance; epidemiological research design
Rights: Creative Common - by 4.0. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
RMID: 1000022631
DOI: 10.20945/2359-3997000000272
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