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https://hdl.handle.net/2440/130692
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dc.contributor.author | Liu, B. | - |
dc.contributor.author | Hutchison, A.T. | - |
dc.contributor.author | Thompson, C.H. | - |
dc.contributor.author | Lange, K. | - |
dc.contributor.author | Wittert, G.A. | - |
dc.contributor.author | Heilbronn, L.K. | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Journal of Clinical Endocrinology and Metabolism, 2021; 106(3):1-11 | - |
dc.identifier.issn | 0021-972X | - |
dc.identifier.issn | 1945-7197 | - |
dc.identifier.uri | http://hdl.handle.net/2440/130692 | - |
dc.description.abstract | Context: Impaired lipid metabolism is linked with obesity-associated insulin resistance, which may be reversed by caloric restriction (CR). Objective: In a secondary analysis of a randomized controlled trial, we compared the effects of intermittent fasting (IF) and CR on markers of lipid metabolism in muscle. Design: Seventy-six women (BMI 25-40 kg/m²) were randomized to one of three diets for eight weeks and provided with foods at 70% (CR70 and IF70) or 100% (IF100) of energy requirements. IF groups ate breakfast, prior to a 24-hour fast on 3 non-consecutive days per week. On non-fasting days, IF70 ate at 100% and IF100 ate at 145% of energy requirements to achieve the prescribed target. Weight, body composition, insulin sensitivity by clamp, non-esterified fatty acids (NEFA), β-hydroxybutyrate, and markers of lipid metabolism and oxidative stress in muscle by qPCR were measured at baseline and week 8 following a 12-hour overnight fast (all groups) and 24-hour fast (IF groups). Results: IF70 resulted in greater weight and fat losses and reduced NEFA versus CR70 and IF100 after an overnight fast. IF70 and IF100 induced a greater reduction only in mRNA levels of antioxidant enzymes GPX1, SOD1 and SOD2 versus CR70. Fasting for 24-hours increased NEFA and β-hydroxybutyrate in IF groups, but impaired insulin sensitivity and increased PLIN5 mRNA levels. Conclusoins: In comparison to CR, IF did not increase markers of lipid metabolism in muscle, but reduced expression of antioxidant enzymes. However, fasting-induced insulin resistance was detected, alongside increased PLIN5 expression, potentially reflecting transient lipid storage. | - |
dc.description.statementofresponsibility | Bo Liu, Amy T. Hutchison, Campbell H. Thompson, Kylie Lange, Gary A. Wittert, and Leonie K. Heilbronn | - |
dc.language.iso | en | - |
dc.publisher | Oxford University Press | - |
dc.rights | © The Author(s) 2020. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com | - |
dc.source.uri | http://dx.doi.org/10.1210/clinem/dgaa707 | - |
dc.subject | Calorie restriction; intermittent fasting; lipid metabolism; mitochondria; muscle; obesity | - |
dc.title | Effects of intermittent fasting or calorie restriction on markers of lipid metabolism in human skeletal muscle | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1210/clinem/dgaa707 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1023401 | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/FT120100027 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Liu, B. [0000-0003-3101-650X] | - |
dc.identifier.orcid | Hutchison, A.T. [0000-0002-6393-3671] | - |
dc.identifier.orcid | Thompson, C.H. [0000-0002-5164-3327] | - |
dc.identifier.orcid | Lange, K. [0000-0003-3814-8513] | - |
dc.identifier.orcid | Wittert, G.A. [0000-0001-6818-6065] | - |
dc.identifier.orcid | Heilbronn, L.K. [0000-0003-2106-7303] | - |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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