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Type: Journal article
Title: Fingertip whole blood as an indicator of omega-3 long-chain polyunsaturated fatty acid changes during dose-response supplementation in women: comparison with plasma and erythrocyte fatty acids
Author: Meyer, B.J.
Sparkes, C.
Sinclair, A.J.
Gibson, R.A.
Else, P.L.
Citation: Nutrients, 2021; 13(5):1419-1-1419-10
Publisher: MDPI AG
Issue Date: 2021
ISSN: 2072-6643
Statement of
Barbara J. Meyer, Cassandra Sparkes, Andrew J. Sinclair, Robert A. Gibson and Paul L. Else
Abstract: The sensitivity of fingertip whole blood to reflect habitual dietary and dose-dependent supplemental omega-3 long-chain polyunsaturated fatty acid (n-3 LCPUFA) intake in premenopausal women was compared to that of venous erythrocytes and plasma fatty acids. Samples were obtained from women in a randomised, double-blind, placebo-controlled trial in which premenopausal women (n = 53) were supplemented with DHA-rich tuna oil capsules and/or placebo (Sunola oil) capsules (6 capsules per day) for 8 weeks to achieve doses of either 0, 0.35, 0.7 or 1.05 g/day n-3 LCPUFA. All blood biomarkers were very similar in their ability to reflect dietary n-3 LCPUFA intake (r = 0.38–0.46 for EPA and DHA intake), and in their dose-dependent increases in n-3 LCPUFA levels after supplementation (R2 = 0.41–0.51 for dose effect on biomarker EPA and DHA levels (mol %)). Fingertip whole blood is an effective alternative to erythrocytes and plasma as a biomarker n-3 LCPUFA intake in premenopausal women.
Keywords: Omega-3; erythrocyte; plasma; whole blood; dose response
Rights: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
DOI: 10.3390/nu13051419
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