Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/130740
Type: Thesis
Title: Modifying Post-Surgical Wound Healing
Author: Vediappan, Rajan Sundaresan
Issue Date: 2021
School/Discipline: Adelaide Medical School
Abstract: “Surgery is a profession defined by its authority to cure by means of bodily invasion. The brutality and risks of opening a living person's body have long been apparent, the benefits only slowly and haltingly worked out”, says Atul Rawande on reviewing 200 yrs. of Surgery as a specialty in NEJM. My research focuses on working out these benefits, specifically looking at reduction of scar tissue formation in ENT, Abdominal & Spine surgery. Scar tissue formation is an outcome of healing process that can be excessive due to inflammation or infection and thereby has the ability to curtail the benefits or warrant revision surgery. Multiple strategies have been tested and employed thus far and none have given favourable results without causing additional harm or economic burden in health care costs. I propose to use a hydrogel synthesized by combining Chitosan and Dextran aldehyde -Chitin is an exoskeleton extracted polymer and Dextran Aldehyde a sugar, with added noveldrugs Deferiprone and Gallium Protoporphyrin providing additional anti scaring and antibiotic properties which could potentially augment the healing properties of the gel. I have conducted 3 types of studies. There are 2 animal studies and a Phase 1 Human clinical trial. The animal studies are an abdominal surgery rat model and a spine surgery sheep model. These studies show the safety and efficacy of this chitogel-drug combination at various dosages and illustrate the healing benefits of gel-drug combination.
Advisor: Wormald, Peter-John
Psaltis, Alkis James
Vreugde, Sarah
Dissertation Note: Thesis (Ph.D.) -- University of Adelaide, Adelaide Medical School, 2021
Keywords: Chronic rhinosinusitus
Chitogel (TM)
absorbable packing
biomaterials
drug eluting stents
endoscopic sinus surgery
haemostatis
nasal packing
removable packing
rhinology
wound healing
Kaolin
abdonimal adhesion
animal model
fibrosis
anti adhesive agent
back pain
epidural adhesion
sheep laminectomy
failed back surgery syndrome
Provenance: This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exceptions. If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at: http://www.adelaide.edu.au/legals
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