Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/130824
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Type: Journal article
Title: Survivors of intensive care with type 2 diabetes and the effect of shared care follow-up clinics: the SWEET-AS randomized controlled pilot study
Author: Ali Abdelhamid, Y.
Phillips, L.K.
White, M.G.
Presneill, J.
Horowitz, M.
Deane, A.M.
Citation: Chest, 2021; 159(1):174-185
Publisher: Elsevier
Issue Date: 2021
ISSN: 0012-3692
1931-3543
Statement of
Responsibility: 
Yasmine Ali Abdelhamid, Liza K. Phillips, Mary G. White, Jeffrey Presneill, Michael Horowitz and Adam M. Deane
Abstract: BACKGROUND: Follow-up clinics after Intensive Care Unit (ICU) admission have demonstrated limited benefit. However, existing trials have evaluated heterogeneous cohorts and utilized physicians who had limited training in outpatient care. RESEARCH QUESTION: What are the effects of a 'shared-care' intensivist-endocrinologist clinic for ICU survivors with type 2 diabetes on process measures and clinical outcomes at 6 months after hospital discharge and is it feasible to conduct a larger trial? STUDY DESIGN: and Methods: This was a prospective, randomized, single-centre pilot study with blinded outcome assessment. Patients with type 2 diabetes, who required ≥ 5 days of ICU care (mixed medical-surgical ICU) and survived to ICU discharge were eligible. Participants were randomized to attendance at the shared-care clinic one month after hospital discharge or usual care. Six months after hospital discharge, participants were assessed for outcomes including glycated hemoglobin, neuropathy, nephropathy, quality of life (QoL), return to employment, frailty and healthcare utilization. The primary outcome was participant recruitment and retention. RESULTS: During an 18-month period, 42 of 82 (51%) eligible patients were recruited. Four participants (10%) withdrew before assessment at 6 months and 11 (26%) died. At 6 months, only 18 (47%) of 38 participants who did not withdraw were living independently without supports and 24 (63%) required at least one subsequent hospital admission. In the intervention group (n=21), 16 (76%) attended the clinic. Point estimates did not indicate that the intervention improved glycated hemoglobin [+5.6 mmol/mol, 95% CI -6.3 to 17; P=0.36] or QoL [Short Form-36 physical summary score 32 (9) vs. 32 (7); P=1.0]. INTERPRETATION: Outcomes for ICU survivors with type 2 diabetes are poor. Due to low participation and high mortality, a larger trial of a shared-care follow-up clinic in this cohort using the present design does not appear feasible.
Keywords: aftercare
critical illness
diabetes mellitus
follow-up studies
randomized controlled trial
recovery
type II
Rights: ©2020 American College of Chest Physicians. Published byElsevier Inc. All rights reserved.
DOI: 10.1016/j.chest.2020.08.011
Published version: http://dx.doi.org/10.1016/j.chest.2020.08.011
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