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Type: Journal article
Title: Stellate porous silica based surface-enhanced Raman scattering system for traceable gene delivery
Author: Liu, L.
Du, X.
Citation: Chinese Chemical Letters, 2021; 32(6):1942-1946
Publisher: Elsevier BV
Issue Date: 2021
ISSN: 1001-8417
Statement of
Lei Liu, Xin Du
Abstract: Numerous nanocarriers have been currently developed for intracellular delivery. The potential cytotoxicity of these very small inorganic nanocarriers has raised great consideration. Thus, it becomes of utmost importance to conduct the intracellular trace of nanocarriers. Among many analytical techniques, surface enhanced Raman scattering (SERS) method is one of the current state-of-the-art techniques for cell visualization and trace. In this work, a novel stellate porous silica based gene delivery system has been designed for SERS trace purpose. A stellate porous silica nanoparticle modified with many small Au nanoparticles is designed to replace common metallic SERS tags. The results show that the designed system not only could deliver siRNA into cells for therapy, but also could realize SERS trace with high sensitivity and non-invasive features. The constructed delivery system has considerable potential to trace the dynamic gene delivery in living cells.
Keywords: Stellate porous silica; Au nanoparticles; Surface-enhanced Raman scattering; SERS trace; Gene delivery
Description: Available online 5 January 2021
Rights: © 2021 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
DOI: 10.1016/j.cclet.2020.12.061
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Appears in Collections:Aurora harvest 4
Chemical Engineering publications

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