Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/130872
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Type: Journal article
Title: In utero substrate restriction by placental insufficiency or maternal undernutrition decreases optical redox ratio in foetal perirenal fat
Author: Lazniewska, J.
Darby, J.R.T.
Holman, S.L.
Sorvina, A.
Plush, S.E.
Massi, M.
Brooks, D.A.
Morrison, J.L.
Citation: Journal of Biophotonics, 2021; 14(4):e202000322-1-e202000322-13
Publisher: Wiley
Issue Date: 2021
ISSN: 1864-063X
1864-0648
Statement of
Responsibility: 
Joanna Lazniewska, Jack R.T. Darby, Stacey L. Holman, Alexandra Sorvina, Sally E. Plush, Massimiliano Massi, Doug A. Brooks, Janna L. Morrison
Abstract: Intrauterine growth restriction (IUGR) can result from reduced delivery of substrates, including oxygen and glucose, during pregnancy and may be caused by either placental insufficiency or maternal undernutrition. As a consequence of IUGR, there is altered programming of adipose tissue and this can be associated with metabolic diseases later in life. We have utilised two sheep models of IUGR, placental restriction and late gestation undernutrition, to determine the metabolic effects of growth restriction on foetal perirenal adipose tissue (PAT). Two-photon microscopy was employed to obtain an optical redox ratio, which gives an indication of cell metabolism. PAT of IUGR foetuses exhibited higher metabolic activity, altered lipid droplet morphology, upregulation of cytochrome c oxidase subunit genes and decreased expression of genes involved in growth and differentiation. Our results indicate that there are adaptations in PAT of IUGR foetuses that might be protective and ensure survival in response to an IUGR insult.
Keywords: Adipose tissue; foetal growth; intrauterine growth restriction; metabolism; redox ratio; substrate supply; two-photon microscopy
Rights: © 2021 Wiley-VCH GmbH
DOI: 10.1002/jbio.202000322
Grant ID: http://purl.org/au-research/grants/arc/FT170100431
Published version: http://dx.doi.org/10.1002/jbio.202000322
Appears in Collections:Aurora harvest 4
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