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Type: Journal article
Title: The p53-caspase-2 axis in the cell cycle and DNA damage response
Author: Lim, Y.
Dorstyn, L.
Kumar, S.
Citation: Experimental and Molecular Medicine, 2021; 53(4):517-527
Publisher: Korean Society of Medical Biochemistry and Molecular Biology
Issue Date: 2021
ISSN: 0378-8512
Statement of
Yoon Lim, Loretta Dorstyn and Sharad Kumar
Abstract: Caspase-2 was discovered almost three decades ago. It was one of the first two mammalian homologs of CED-3, the other being interleukin 1β-converting enzyme (ICE/caspase-1). Despite high similarity with CED-3 and its fly and mammalian counterparts (DRONC and caspase-9, respectively), the function of caspase-2 in apoptosis has remained enigmatic. A number of recent studies suggest that caspase-2 plays an important role in the regulation of p53 in response to cellular stress and DNA damage to prevent the proliferation and accumulation of damaged or aberrant cells. Here, we review these recent observations and their implications in caspase-2-mediated cellular death, senescence, and tumor suppression.
Keywords: Animals
DNA Damage
Disease Susceptibility
Signal Transduction
Cell Cycle
Gene Expression Regulation
Enzyme Activation
Tumor Suppressor Protein p53
Caspase 2
Stress, Physiological
Protein Stability
Rights: © The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any mediumor format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changesweremade. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
DOI: 10.1038/s12276-021-00590-2
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Appears in Collections:Aurora harvest 4
Molecular and Biomedical Science publications

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