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Type: Journal article
Title: Efficacy and safety of statins in ethnic differences: a lesson for application in Indigenous Australian patient care
Author: Gebremichael, L.G.
Suppiah, V.
Wiese, M.D.
Mackenzie, L.
Phillips, C.
Williams, D.B.
Roberts, M.S.
Citation: Pharmacogenomics, 2021; 22(9):553-571
Publisher: Future Medicine
Issue Date: 2021
ISSN: 1462-2416
Statement of
Lemlem G Gebremichael, Vijayaprakash Suppiah, Michael D Wiese, Lorraine Mackenzie, Craig Phillips, Desmond B Williams, Michael S Roberts
Abstract: Although statins are effective in treating high cholesterol, adverse effects do occur with their use. Efficacy and tolerability vary among statins in different ethnic groups. Indigenous Australians have a high risk for cardiovascular and kidney diseases. Prescribing statins to Indigenous Australians with multi-morbidity requires different strategies to increase efficacy and reduce their toxicity. Previous studies have reported that Indigenous Australians are more susceptible to severe statin-induced myopathies. However, there is a lack of evidence in the underlying genetic factors in this population. This review aims to identify: inter-ethnic differences in the efficacy and safety of statins; major contributing factors accounting for any identified differences; and provide an overview of statin-induced adverse effects in Indigenous Australians.
Keywords: Indigenous
ethnic groups
Rights: © 2021 Future Medicine Ltd.
DOI: 10.2217/pgs-2020-0152
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