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Type: Journal article
Title: Pruritogenic mechanisms and gut sensation: putting the "irritant" into irritable bowel syndrome
Author: Brizuela, M.
Castro, J.
Harrington, A.M.
Brierley, S.M.
Citation: American Journal of Physiology: Gastrointestinal and Liver Physiology, 2021; 320(6):G1131-G1141
Publisher: American Physiological Society
Issue Date: 2021
ISSN: 0193-1857
Statement of
Mariana Brizuela, Joel Castro, Andrea M. Harrington, and Stuart M. Brierley
Abstract: Chronic abdominal pain is a common clinical condition experienced by patients with irritable bowel syndrome (IBS). A general lack of suitable treatment options for the management of visceral pain is the major contributing factor to the debilitating nature of the disease. Understanding the underlying causes of chronic visceral pain is pivotal to identifying new effective therapies for IBS. This review provides the current evidence, demonstrating that mediators and receptors that induce itch in the skin also act as "gut irritants" in the gastrointestinal tract. Activation of these receptors triggers specific changes in the neuronal excitability of sensory pathways responsible for the transmission of nociceptive information from the periphery to the central nervous system leading to visceral hypersensitivity and visceral pain. Accumulating evidence points to significant roles of irritant mediators and their receptors in visceral hypersensitivity and thus constitutes potential targets for the development of more effective therapeutic options for IBS.
Keywords: GPCRs; histamine; itch; proteases; visceral hypersensitivity
Rights: © 2021 the American Physiological Society
RMID: 1000042304
DOI: 10.1152/ajpgi.00331.2020
Grant ID:
Appears in Collections:Medicine publications

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