Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/131224
Type: Thesis
Title: Quality of Life in Multiple Sclerosis: A Meta-analytic Review
Author: Pedram Khou, Maryam
Issue Date: 2020
School/Discipline: School of Psychology
Abstract: Background: Multiple Sclerosis (MS) is a disabling disease that can have a substantial impact on quality of life (QoL). However, use of various assessment instruments to assess QoL, in addition to demographic and MS characteristics, may produce different results. Aim: To examine QoL differences between adults with MS and healthy controls as well as the potential moderating role of demographic and disease characteristics (i.e. age, years since diagnosis, disability severity). Methods: Thirty-five eligible studies (3,493 MS, 187,296 controls) were identified from a search of the CINAHL, Embase, PsycINFO, PubMed, and Scopus databases. Methodological rigour of the included studies was evaluated using the National Institute of Health Quality Assessment Tool. Group mean differences in QoL were standardised by calculating Hedges’ g. In addition, 95% confidence intervals, p values, failsafe Ns, and heterogeneity statistics (Cochran’s Q, I-squared, and tau) were computed, using a random effects model. Sources of between-study variability were examined with a multivariate meta-regression. Results: Mean QoL ratings were significantly lower for adults with MS compared to healthy peers (gw = -0.907, CI -1.168 to -0.654, p <.01), although effect sizes varied markedly across QoL domains (gw range = -.31 to – 1.15). Older age, years since diagnosis, and disability impairment explained 38% of the variance seen. Conclusion: The findings suggest that QoL should be routinely measured in clinical research and practice as a study outcome. Multidisciplinary interventions provided on an ongoing basis can ensure that care needs are met with disease progression.
Dissertation Note: Thesis (B.PsychSc(Hons)) -- University of Adelaide, School of Psychology, 2020
Keywords: Honours; Psychology
Description: This item is only available electronically.
Provenance: This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exceptions. If you are the author of this thesis and do not wish it to be made publicly available, or you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at: http://www.adelaide.edu.au/legals
Appears in Collections:School of Psychology

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