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Type: Journal article
Title: Neurokinin 3 receptor antagonism ameliorates key metabolic features in a hyperandrogenic PCOS mouse model
Author: Sucquart, I.E.
Nagarkar, R.
Edwards, M.C.
Rodriguez Paris, V.
Aflatounian, A.
Bertoldo, M.J.
Campbell, R.E.
Gilchrist, R.B.
Begg, D.P.
Handelsman, D.J.
Padmanabhan, V.
Anderson, R.A.
Walters, K.A.
Citation: Endocrinology, 2021; 162(5):1-15
Publisher: The Endocrine Society
Issue Date: 2021
ISSN: 0013-7227
Statement of
Irene E Sucquart, Ruchi Nagarkar, Melissa C Edwards, Valentina Rodriguez Paris, Ali Aflatounian, Michael J Bertoldo ... et al.
Abstract: Polycystic ovary syndrome (PCOS) is a prevalent endocrine condition characterised by a range of endocrine, reproductive and metabolic abnormalities. At present, management of women with PCOS is suboptimal as treatment is only symptomatic. Clinical and experimental advances in our understanding of PCOS etiology support a pivotal role for androgen neuroendocrine actions in PCOS pathogenesis. Hyperandrogenism is a key PCOS trait and androgen actions play a role in regulating the kisspeptin-/neurokinin B-/dynorphin (KNDy) system. This study aimed to investigate if targeted antagonism of neurokinin B signalling through the neurokinin 3 receptor (NK3R) would reverse PCOS traits in a dihydrotestosterone (DHT)-induced mouse model of PCOS. After 3 months, DHT exposure induced key reproductive PCOS traits of cycle irregularity and ovulatory dysfunction, and PCOS-like metabolic traits including increased body weight; white and brown fat pad weights; fasting serum triglyceride and glucose levels and blood glucose iAUC. Treatment with a NK3R antagonist (MLE4901) did not impact the observed reproductive defects. In contrast, following NK3R antagonist treatment, PCOS-like females displayed decreased total body weight, adiposity and adipocyte hypertrophy, but increased respiratory exchange ratio, suggesting NK3R antagonism altered the metabolic status of the PCOS-like females. NK3R antagonism did not improve circulating serum triglyceride or fasted glucose levels. Collectively, these findings demonstrate that NK3R antagonism may be beneficial in the treatment of adverse metabolic features associated with PCOS and support neuroendocrine targeting in the development of novel therapeutic strategies for PCOS.
Keywords: animal model; hyperandrogenism; neuroendocrine; polycystic ovary syndrome (PCOS)
Rights: © The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved.
RMID: 1000035156
DOI: 10.1210/endocr/bqab020
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Appears in Collections:Medicine publications

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