Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/131258
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Type: Journal article
Title: The adaptation and investigation of cone-beam CT reconstruction algorithms for horizontal rotation fixed-gantry scans of rabbits
Author: Gardner, M.
Dillon, O.
Shieh, C.-.C.
O'Brien, R.T.
Debrot, E.
Barber, J.
Ahern, V.
Bennett, P.
Heng, S.-.M.
Corde, S.
Jackson, M.
Keall, P.J.
Citation: Physics in Medicine and Biology, 2021; 66(10):105012[-1]-105012-[14]
Publisher: IOP Publishing
Issue Date: 2021
ISSN: 0031-9155
1361-6560
Statement of
Responsibility: 
Mark Gardner, Owen Dillon, Chun-Chien Shieh, Ricky O’Brien, Emily Debrot, Jeffrey Barber, Verity Ahern, Peter Bennett, Soo-Min Heng, Stéphanie Corde, Michael Jackson, and Paul Keall
Abstract: Fixed-gantry radiation therapy has been proposed as a low-cost alternative to the conventional rotating-gantry radiation therapy, that may help meet the rising global treatment demand. Fixed-gantry systems require gravitational motion compensated reconstruction algorithms to produce cone-beam CT (CBCT) images of sufficient quality for image guidance. The aim of this work was to adapt and investigate five CBCT reconstruction algorithms for fixed-gantry cone-beam CT images. The five algorithms investigated were Feldkamp-Davis-Kress (FDK), prior image constrained compressed sensing (PICCS), gravitational motion compensated FDK (GMCFDK), motion compensated PICCS (MCPICCS) (a novel CBCT reconstruction algorithm) and simultaneous motion estimation and iterative reconstruction (SMEIR). Fixed-gantry and rotating-gantry CBCT scans were acquired of 3 rabbits, with the rotating-gantry scans used as a reference. Projections were sorted into rotation bins, based on the angle of rotation of the rabbit during image acquisition. The algorithms were compared using the structural similarity index measure root-mean-square error, and reconstruction time. Evaluation of the reconstructed volumes showed that, when compared with the reference rotating-gantry volume, the conventional FDK algorithm did not accurately reconstruct fixed-gantry CBCT scans. Whilst the PICCS reconstruction algorithm reduced some motion artefacts, the motion estimation reconstruction methods (GMCFDK, MCPICCS and SMEIR) were able to greatly reduce the effect of motion artefacts on the reconstructed volumes. This finding was verified quantitatively, with GMCFDK, MCPICCS and SMEIR reconstructions having RMSE 17-19% lower and SSIM 1% higher than a conventional FDK. However, all motion compensated fixed-gantry CBCT reconstructions had a 56-61% higher RMSE and 1.5% lower SSIM than FDK reconstructions of conventional rotating-gantry CBCT scans. The results show that motion compensation is required to reduce motion artefacts for fixed-gantry CBCT reconstructions. This paper further demonstrates the feasibility of fixed-gantry CBCT scans, and the ability of CBCT reconstruction algorithms to compensate for motion due to horizontal rotation.
Keywords: CBCT; image reconstruction; motion compensation; animal study; radiotherapy
Rights: © 2021 Institute of Physics and Engineering in Medicine
RMID: 1000040006
DOI: 10.1088/1361-6560/abf9dd
Appears in Collections:Medicine publications

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