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Type: Journal article
Title: Physiological functions of bacterial “multidrug” efflux pumps
Author: Henderson, P.J.F.
Maher, C.
Elbourne, L.D.H.
Eijkelkamp, B.A.
Paulsen, I.T.
Hassan, K.A.
Citation: Chemical Reviews, 2021; 121(9):5417-5478
Publisher: American Chemical Society
Issue Date: 2021
ISSN: 0009-2665
Statement of
Peter J. F. Henderson, Claire Maher, Liam D. H. Elbourne, Bart A. Eijkelkamp, Ian T. Paulsen, and Karl A. Hassan
Abstract: Bacterial multidrug efflux pumps have come to prominence in human and veterinary pathogenesis because they help bacteria protect themselves against the antimicrobials used to overcome their infections. However, it is increasingly realized that many, probably most, such pumps have physiological roles that are distinct from protection of bacteria against antimicrobials administered by humans. Here we undertake a broad survey of the proteins involved, allied to detailed examples of their evolution, energetics, structures, chemical recognition, and molecular mechanisms, together with the experimental strategies that enable rapid and economical progress in understanding their true physiological roles. Once these roles are established, the knowledge can be harnessed to design more effective drugs, improve existing microbial production of drugs for clinical practice and of feedstocks for commercial exploitation, and even develop more sustainable biological processes that avoid, for example, utilization of petroleum.
Keywords: Animals
Membrane Transport Proteins
Anti-Bacterial Agents
Drug Resistance, Microbial
Bacterial Outer Membrane
Rights: © 2021 American Chemical Society
DOI: 10.1021/acs.chemrev.0c01226
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Appears in Collections:Aurora harvest 8
Chemistry publications

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