Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/131271
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Type: Journal article
Title: Understanding mast cell heterogeneity at single cell resolution
Author: Cildir, G.
Yip, K.H.
Pant, H.
Tergaonkar, V.
Lopez, A.F.
Tumes, D.J.
Citation: Trends in Immunology, 2021; 42(6):523-535
Publisher: Elsevier BV
Issue Date: 2021
ISSN: 1471-4906
1471-4981
Statement of
Responsibility: 
Gökhan Cildir, Kwok Ho Yip, Harshita Pant, Vinay Tergaonkar, Angel F. Lopez, and Damon J. Tumes
Abstract: Mast cells (MC)s are evolutionarily conserved, tissue-resident immune cells with diverse roles in allergy, cancer, and protection from infection by helminths and microorganisms. The significant diversity in MC development and tissue-specific functional characteristics has recently begun to be understood. Exciting developments in single-cell-based RNA, protein, and chromatin profiling technologies offer new opportunities to characterize MC heterogeneity and to uncover novel MC functions and subtypes; these developments might lead to new and clinically effective therapies for certain pathologies. In this review, we provide an overview of the current understanding of MC development and heterogeneity and discuss new insights gained from single-cell-based studies that may lead to future research directions and therapeutic opportunities.
Keywords: Mast cells; single-cell RNA-seq; epigenetics; transcription factors; allergy; asthma
Rights: © 2021 Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.it.2021.04.004
Grant ID: http://purl.org/au-research/grants/nhmrc/1127290
http://purl.org/au-research/grants/nhmrc/1182564
http://purl.org/au-research/grants/nhmrc/2004288
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