Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/131330
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Type: Journal article
Title: Defining the impact of dietary macronutrient balance on PCOS traits
Author: Rodriguez Paris, V.
Solon-Biet, S.M.
Senior, A.M.
Edwards, M.C.
Desai, R.
Tedla, N.
Cox, M.J.
Ledger, W.L.
Gilchrist, R.B.
Simpson, S.J.
Handelsman, D.J.
Walters, K.A.
Citation: Nature Communications, 2020; 11(1):1-15
Publisher: Nature
Issue Date: 2020
ISSN: 2041-1723
2041-1723
Statement of
Responsibility: 
Valentina Rodriguez Paris, Samantha M. Solon-Biet, Alistair M. Senior, Melissa C. Edwards Reena Desai, Nicodemus Tedla
Abstract: Lifestyle, mainly dietary, interventions are first-line treatment for women with polycystic ovary syndrome (PCOS), but the optimal diet remains undefined. We combined a hyperandrogenized PCOS mouse model with a systematic macronutrient approach, to elucidate the impact of dietary macronutrients on the development of PCOS. We identify that an optimum dietary macronutrient balance of a low protein, medium carbohydrate and fat diet can ameliorate key PCOS reproductive traits. However, PCOS mice display a hindered ability for their metabolic system to respond to diet variations, and varying macronutrient balance did not have a beneficial effect on the development of metabolic PCOS traits. We reveal that PCOS traits in a hyperandrogenic PCOS mouse model are ameliorated selectively by diet, with reproductive traits displaying greater sensitivity than metabolic traits to dietary mac ronutrient balance. Hence, providing evidence to support the development of evidence-based dietary interventions as a promising strategy for the treatment of PCOS, especially repro ductive traits.
Keywords: Animals
Mice, Inbred C57BL
Humans
Mice
Polycystic Ovary Syndrome
Diet, Protein-Restricted
Diet
Life Style
Female
Nutrients
Rights: © The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright hold.
DOI: 10.1038/s41467-020-19003-5
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