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Type: Journal article
Title: 3D bioprinting of a cell-laden antibacterial polysaccharide hydrogel composite
Author: Rastin, H.
Ramezanpour, M.
Hassan, K.
Mazinani, A.
Tung, T.T.
Vreugde, S.
Losic, D.
Citation: Carbohydrate Polymers, 2021; 264:117989-1-117989-12
Publisher: Elsevier
Issue Date: 2021
ISSN: 0144-8617
Statement of
Hadi Rastin, Mahnaz Ramezanpour, Kamrul Hassan, Arash Mazinani, Tran Thanh Tung, Sarah Vreugde, Dusan Losic
Abstract: Bioink with inherent antibacterial activity is of particular interest for tissue engineering application due to the growing number of bacterial infections associated with impaired wound healing or bone implants. However, the development of cell-laden bioink with potent antibacterial activity while supporting tissue regeneration proved to be challenging. Here, we introduced a cell-laden antibacterial bioink based on Methylcellulose/Alginate (MC/ Alg) hydrogel for skin tissue engineering via elimination of the risks associated with a bacterial infection. The key feature of the bioink is the use of gallium (Ga+3) in the design of bioink formulation with dual functions. First, Ga+3 stabilized the hydrogel bioink by the formation of ionic crosslinking with Alg chains. Second, the gallium- crosslinked bioink exhibited potent antibacterial activity toward both Gram-positive (Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa) bacteria with a bactericidal rate of 99.99 %. In addition, it was found that the developed bioink supported encapsulated fibroblast cellular functions.
Keywords: Antibacterial activity; bioink; skin tissue engineering; gallium
Rights: Crown Copyright © 2021 Published by Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.carbpol.2021.117989
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Appears in Collections:ARC Research Hub for Graphene Enabled Industry Transformation publications
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