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Type: Journal article
Title: Regulation of mRNA translation by hormone receptors in breast and prostate cancer
Author: Xie, J.
Kusnadi, E.P.
Furic, L.
Selth, L.A.
Citation: Cancers, 2021; 13(13):3254-1-3254-26
Publisher: MDPI AG
Issue Date: 2021
ISSN: 2072-6694
Statement of
Jianling Xie, Eric P. Kusnadi, Luc Furic and Luke A. Selth
Abstract: Breast and prostate cancer are the second and third leading causes of death amongst all cancer types, respectively. Pathogenesis of these malignancies is characterised by dysregulation of sex hormone signalling pathways, mediated by the estrogen receptor-α (ER) in breast cancer and androgen receptor (AR) in prostate cancer. ER and AR are transcription factors whose aberrant function drives oncogenic transcriptional programs to promote cancer growth and progression. While ER/AR are known to stimulate cell growth and survival by modulating gene transcription, emerging findings indicate that their effects in neoplasia are also mediated by dysregulation of protein synthesis (i.e., mRNA translation). This suggests that ER/AR can coordinately perturb both transcriptional and translational programs, resulting in the establishment of proteomes that promote malignancy. In this review, we will discuss relatively understudied aspects of ER and AR activity in regulating protein synthesis as well as the potential of targeting mRNA translation in breast and prostate cancer.
Keywords: Androgen receptor; breast cancer; estrogen receptor; mRNA translation; mTOR; prostate cancer; protein synthesis
Rights: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
DOI: 10.3390/cancers13133254
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