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Type: Journal article
Title: Impact of cardiometabolic factors on retinal vasculature: A 3x3, 6x6 and 8x8-mm optical coherence tomography angiography study
Author: Sun, M.T.
Huang, S.
Chan, W.
Craig, J.E.
Knight, L.S.W.
Sanders, P.
Newland, H.
Casson, R.
Selva, D.
Wong, C.X.
Citation: Clinical and Experimental Ophthalmology, 2021; 49(3):260-269
Publisher: Wiley
Issue Date: 2021
ISSN: 1442-6404
Statement of
Michelle T. Sun, Sonia Huang, WengOnn Chan, Jamie E. Craig, Lachlan S. W. Knight, Prashanthan Sanders ... et al.
Abstract: Background: Optical coherence tomography angiography (OCTA) is available in varying size and resolution. We sought to characterize associations of cardiometabolic factors with retinal microvascular changes using 3x3-mm, 6x6-mm and 8x8-mm OCTA scans to determine differences in detection with varying scan size. Methods: Cross-sectional study of 247 cardiovascular patients from a single-centre tertiary-care hospital. Demographic, comorbidity, and medication data were obtained. Patients underwent 3x3-mm, 6x6-mm and 8x8-mm macula OCTA scanning using Carl Zeiss CIRRUS HD-OCT Model 5000. Angioplex and AngioTool software was used to quantify vascular parameters in the superficial capillary plexus.Results: Increasing age, hypertension, dyslipidemia, diabetes, chronic kidney disease, coronary artery disease, and peripheral vascular disease were associated with reductions in vessel density, vessel perfusion, average vessel length and/or junction density in 3x3-mm OCTA (p<0.05 for all). Conversely, smoking was associated with increased vessel density, vessel length, and junction density in 3x3-mm OCTA (p<0.05 for all). Associations of vessel abnormalities with cardiometabolic factors were progressively weakened and statistically attenuated in 6x6-mm and 8x8-mm OCTA scans. In multivariate analyses, dyslipidemia remained an independent predictor of reduced vessel density, average vessel length, and junction density (p<0.05). Conclusions: Cardiometabolic factors are associated with multiple retinal microvascular changes in 3x3-mm OCTA scans. These associations were weakened and progressively attenuated in OCTA scans of larger 6x6-mm and 8x8-mm size. These findings advance our understanding of microcirculatory dysfunction and may have future implications for the screening and management of patients with cardiometabolic risk factors. Additional studies are required to further investigate these important associations.
Keywords: Cardiovascular disease
Retinal vasculature
Rights: © 2021 Royal Australian and New Zealand College of Ophthalmologists
DOI: 10.1111/ceo.13913
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