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Type: Book chapter
Title: Drosophila as a model to understand autophagy deregulation in human disorders
Author: Denton, D.
O'Keefe, L.
Kumar, S.
Citation: Progress in Molecular Biology and Translational Science, 2020 / Martinez, A.B., Galluzzi, L. (ed./s), vol.172, Ch.15, pp.375-409
Publisher: Academic Press
Publisher Place: Cambridge, MA; United States
Issue Date: 2020
Series/Report no.: Progress in Molecular Biology and Translational Science
ISBN: 9780128220214
Editor: Martinez, A.B.
Galluzzi, L.
Statement of
Donna Denton, Louise O'Keefe, Sharad Kumar
Abstract: Autophagy has important functions in normal physiology to maintain homeostasis and protect against cellular stresses by the removal of harmful cargos such as dysfunctional organelles, protein aggregates and invading pathogens. The deregulation of autophagy is a hallmark of many diseases and therapeutic targeting of autophagy is highly topical. With the complex role of autophagy in disease it is essential to understand the genetic and molecular basis of the contribution of autophagy to pathogenesis. The model organism, Drosophila, provides a genetically amenable system to dissect out the contribution of autophagy to human disease models. Here we review the roles of autophagy in human disease and how autophagy studies in Drosophila have contributed to the understanding of pathophysiology.
Keywords: Animals
Drosophila melanogaster
Cell Transformation, Neoplastic
Neurodegenerative Diseases
Lysosomal Storage Diseases
Disease Models, Animal
Drosophila Proteins
Tumor Suppressor Proteins
Drug Screening Assays, Antitumor
Organ Specificity
DNA Repeat Expansion
Conserved Sequence
Neoplastic Stem Cells
Drug Discovery
Imaginal Discs
Autophagy-Related Proteins
Rights: © 2020 Elsevier. All rights reserved.
DOI: 10.1016/bs.pmbts.2020.01.005
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Appears in Collections:Aurora harvest 8
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