Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/131736
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Type: Journal article
Title: Homeostatic apoptosis prevents competition-induced atrophy in follicular B cells
Author: Chappaz, S.
McArthur, K.
Kealy, L.
Law, C.W.
Tailler, M.
Lane, R.M.
Lieschke, A.
Ritchie, M.E.
Good-Jacobson, K.L.
Strasser, A.
Kile, B.T.
Citation: Cell Reports, 2021; 36(3):1-7
Publisher: CellPress
Issue Date: 2021
ISSN: 2211-1247
2211-1247
Statement of
Responsibility: 
Stéphane Chappaz, Kate McArthur, Liam Kealy, Charity W. Law, Maximilien Tailler, Rachael M. Lane ... et al.
Abstract: While the intrinsic apoptosis pathway is thought to play a central role in shaping the B cell lineage, its precise role in mature B cell homeostasis remains elusive. Using mice in which mature B cells are unable to undergo apoptotic cell death, we show that apoptosis constrains follicular B (FoB) cell lifespan but plays no role in marginal zone B (MZB) cell homeostasis. In these mice, FoB cells accumulate abnormally. This intensifies intercellular competition for BAFF, resulting in a contraction of the MZB cell compartment, and reducing the growth, trafficking, and fitness of FoB cells. Diminished BAFF signaling dampens the non-canonical NF-κB pathway, undermining FoB cell growth despite the concurrent triggering of a protective p53 response. Thus, MZB and FoB cells exhibit a differential requirement for the intrinsic apoptosis pathway. Homeostatic apoptosis constrains the size of the FoB cell compartment, thereby preventing competition-induced FoB cell atrophy.
Keywords: Thymus Gland
B-Lymphocytes
Animals
Mice, Knockout
Atrophy
Transcription Factors
Cell Count
Sequence Analysis, RNA
Apoptosis
Cell Differentiation
Cell Proliferation
Cell Size
Cell Survival
Antibody Formation
Gene Expression Regulation
Gene Deletion
Homeostasis
bcl-2 Homologous Antagonist-Killer Protein
bcl-2-Associated X Protein
B-Cell Activating Factor
Cellular Senescence
Rights: © 2021 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
DOI: 10.1016/j.celrep.2021.109430
Grant ID: http://purl.org/au-research/grants/nhmrc/1077750
http://purl.org/au-research/grants/nhmrc/1106471
http://purl.org/au-research/grants/nhmrc/1016647
http://purl.org/au-research/grants/nhmrc/101671
http://purl.org/au-research/grants/nhmrc/1113577
http://purl.org/au-research/grants/nhmrc/1161352
http://purl.org/au-research/grants/nhmrc/1063008
http://purl.org/au-research/grants/nhmrc/1020363
http://purl.org/au-research/grants/nhmrc/361646
Published version: http://dx.doi.org/10.1016/j.celrep.2021.109430
Appears in Collections:Aurora harvest 4
Medicine publications

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