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Type: Journal article
Title: Gastrointestinal autonomic neuropathy in diabetes
Author: Marathe, C.S.
Jones, K.L.
Wu, T.
Rayner, C.K.
Horowitz, M.
Citation: Autonomic Neuroscience: Basic and Clinical, 2020; 229:1-9
Publisher: Elsevier
Issue Date: 2020
ISSN: 1566-0702
Statement of
Chinmay S.Marathe, Karen L.Jones, Tongzhi Wu, Christopher K.Rayner, Michael Horowitz
Abstract: Gastrointestinal autonomic neuropathy represents an important and diverse, but poorly appreciated, manifestation of diabetic autonomic neuropathy that impacts negatively on quality of life. There is no test to assess gastrointestinal autonomic nerve damage directly in humans; cardiovascular autonomic reflex tests are often used as a surrogate, but are suboptimal. Gastrointestinal symptoms are common in diabetes, but usually correlate only weakly with disordered motility. Diabetic gastroparesis, or abnormally delayed gastric emptying, occurs frequently and is the best characterized manifestation of gastrointestinal autonomic neuropathy. There is a bi-directional relationship between postprandial glycaemia and the rate of gastric emptying. However, autonomic neuropathy can affect the function of any gut segment from the esophagus to the anus. Current management options for gastrointestinal autonomic neuropathy are, for the main part, empirical and sub-optimal.
Keywords: Diabetes; gastric emptying; gastroparesis; gastrointestinal autonomic neuropathy
Rights: © 2020 Published by Elsevier B.V.
DOI: 10.1016/j.autneu.2020.102718
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