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Type: Journal article
Title: Genetic relationships between early menopause and the behaviour of theca interna during follicular atresia
Author: Rodgers, R.J.
Laven, J.S.E.
Citation: Human Reproduction, 2020; 35(10):2185-2187
Publisher: Oxford University Press
Issue Date: 2020
ISSN: 0268-1161
Statement of
Raymond J. Rodgers and Joop S.E. Laven
Abstract: Genetic variants are known to contribute to about 50% of the heritability of the age of menopause and recent studies suggest that genes associated with genome maintenance are involved. The idea that increased rates of follicular atresia could lead to depletion of the primoridial follicle reserve and early menopause has also been canvassed, but there is no direct evidence of this. In studies of the transcriptomics of follicular atresia, it was found that in the theca interna, the largest group of genes are in fact down-regulated and associated with 'cell cycle and DNA replication', in contrast with the up-regulation of apoptosis-associated genes which occurs in granulosa cells. Many of the genes down-regulated in the theca interna are the same as or related to the genes in loci associated with early menopause. From these findings, we suggest that early menopause could be due to increased rates of follicular atresia initiated from the theca interna.
Keywords: atresia
genome maintenance
Rights: ©The Author(s) 2020. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology. All rights reserved.
DOI: 10.1093/humrep/deaa173
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Appears in Collections:Aurora harvest 8
Paediatrics publications

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