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Type: Journal article
Title: Nanoparticle elasticity regulates phagocytosis and cancer cell uptake
Author: Hui, Y.
Yi, X.
Wibowo, D.
Yang, G.
Middelberg, A.P.J.
Gao, H.
Zhao, C.X.
Citation: Science Advances, 2020; 6(16):1-11
Publisher: American Association for the Advancement of Science
Issue Date: 2020
ISSN: 2375-2548
Statement of
Yue Hui1, Xin Yi2, David Wibowo1*, Guangze Yang1, Anton P. J. Middelberg3, Huajian Gao4,5†, Chun-Xia Zhao
Abstract: The ability of cells to sense external mechanical cues is essential for their adaptation to the surrounding microenvironment. However, how nanoparticle mechanical properties affect cell-nanoparticle interactions remains largely unknown. Here, we synthesized a library of silica nanocapsules (SNCs) with a wide range of elasticity (Young’s modulus ranging from 560 kPa to 1.18 GPa), demonstrating the impact of SNC elasticity on SNC interactions with cells. Transmission electron microscopy revealed that the stiff SNCs remained spherical during cellular uptake. The soft SNCs, however, were deformed by forces originating from the specific ligand-receptor interaction and membrane wrapping, which reduced their cellular binding and endocytosis rate. This work demonstrates the crucial role of the elasticity of nanoparticles in modulating their macrophage uptake and receptor-mediated cancer cell uptake, which may shed light on the design of drug delivery vectors with higher efficiency.
Keywords: Neoplasms
Silicon Dioxide
Drug Delivery Systems
Rights: © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
DOI: 10.1126/sciadv.aaz4316
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