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Type: Journal article
Title: Characterization of a gene encoding a cysteine-rich keratin associated protein synthesized late in rabbit hair follicle differentiation
Author: Powell, B.
Arthur, J.
Nesci, A.
Citation: Differentiation, 1995; 58(3):227-232
Publisher: Springer-Verlag
Issue Date: 1995
ISSN: 0301-4681
Abstract: Many different cysteine-rich proteins are synthesized during hair follicle differentiation, forming part of the interstitial matrix between bundles of intermediate filaments. We have isolated a rabbit gene (rKAP4L¹), a member of a multi gene family that encodes a small cysteine-rich hair keratin associated protein. This is the first complete gene sequence for this family. The rKAP4L gene is expressed in the cortex of rabbit pelage hair follicles at a late stage of hair follicle differentiation, well after the synthesis of the other major hair proteins, the intermediate filament and glycine/tyrosine-rich keratin associated proteins, has commenced. The protein contains 36 mol % cysteine, with a molecular size of 13593 daltons, and its sequence appears to be based on a pentapeptide repeat. It is predicted to adopt a folded conformation characterized by β-turns interspersed with short stretches of β-sheet or random coil
Keywords: Hair
In Situ Hybridization
Chromosome Mapping
Cell Differentiation
Gene Expression
Amino Acid Sequence
Base Sequence
Sequence Homology, Amino Acid
Sequence Homology, Nucleic Acid
Multigene Family
Molecular Sequence Data
Description: Copyright © 1999-2009 John Wiley & Sons, Inc. All Rights Reserved.
DOI: 10.1046/j.1432-0436.1995.5830227.x
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Appears in Collections:Agriculture, Food and Wine publications
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