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dc.contributor.authorKamei, M.-
dc.contributor.authorWebb, G.-
dc.contributor.authorHeydon, K.-
dc.contributor.authorHendry, I.-
dc.contributor.authorYoung, I.-
dc.contributor.authorCampbell, H.-
dc.identifier.citationGenomics, 2000; 64(1):82-89-
dc.description.abstractThe Drosophila melanogaster small optic lobes gene (sol) is required for normal development of the neuropiles of the medulla and lobula complexes of the adult optic lobes. The predicted protein products of sol and its human homologue SOLH contain zinc-finger-like repeats, a calpain-like protease domain, and a C-terminal domain of unknown function. Long-distance PCR was used to amplify genomic DNA for Solh, the mouse homologue of sol, following the identification of mouse Solh expressed sequence tags. The nucleotide sequence of the Solh coding region (6.0 kb) was determined. The predicted Solh protein of 1095 amino acid residues shows 89% identity (93% similarity) to the human homologue. Solh was localized by in situ hybridization to band A3.3 on mouse Chromosome 17, in a region of maintained homology with human 16p13.3. Antipeptide antibodies were prepared and verified by demonstration of specific reactivity with recombinant human SOLH protein prepared by in vitro transcription/translation and expression in insect cells using the baculovirus system. The antibodies were used to show that the Solh protein localizes to the olfactory bulb in mouse and rat brain, suggesting that it could have an analogous role in development of sensory system neurons in Drosophila and in mammals.-
dc.description.statementofresponsibilityKamei, Makoto; Webb, Graham C.; Heydon, Katrina; Hendry, Ian A.; Young, Ian G.; Campbell, Hugh D.-
dc.publisherAcademic Press Inc Elsevier Science-
dc.subjectOlfactory Bulb-
dc.subjectMice, Inbred BALB C-
dc.subjectMice, Inbred C57BL-
dc.subjectDrosophila melanogaster-
dc.subjectInsect Proteins-
dc.subjectDrosophila Proteins-
dc.subjectNerve Tissue Proteins-
dc.subjectDNA, Complementary-
dc.subjectChromosome Mapping-
dc.subjectCloning, Molecular-
dc.subjectAmino Acid Sequence-
dc.subjectBase Sequence-
dc.subjectZinc Fingers-
dc.subjectSequence Homology, Amino Acid-
dc.subjectExpressed Sequence Tags-
dc.subjectMolecular Sequence Data-
dc.subjectTectum Mesencephali-
dc.subjectOptic Lobe, Nonmammalian-
dc.titleSolh, the mouse homologue of the Drosophila melanogaster small optic lobes gene: organization, chromosomal mapping, and localization of gene product to the olfactory bulb-
dc.typeJournal article-
dc.identifier.orcidKamei, M. [0000-0002-1438-0783]-
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