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Type: Journal article
Title: The genetic architecture of anterior tooth morphology in a longitudinal sample of Australian twins and families
Author: Paul, K.
Stojanowski, C.
Hughes, T.
Brook, A.
Townsend, G.
Citation: Archives of Oral Biology, 2021; 129:105168-1-105168-11
Publisher: Elsevier
Issue Date: 2021
ISSN: 0003-9969
Statement of
Kathleen S. Paul, Christopher M. Stojanowski, Toby Hughes, Alan Brook, Grant C. Townsend
Abstract: Objective: This study presents a quantitative genetic analysis of human anterior dental morphology in a longi-tudinal sample of known genealogy. The primary aim of this work is to generate a suite of genetic correlations within and between deciduous and permanent characters to access patterns of integration across the diphyodont dental complex. Design: Data were recorded from casted tooth crowns representing participants of a long-term Australian twin and family study (deciduous n=290, permanent n=339). Morphological trait expression was observed and scored following Arizona State University Dental Anthropology System standards. Bivariate genetic correlations were estimated using maximum likelihood variance decomposition models in SOLAR v.8.1.1. Results: Genetic correlation estimates indicate high levels of integration between antimeres but low to moderate levels among traits within a tooth row. Only 9% of deciduous model comparisons were significant, while plei-otropy was indicated for one third of permanent trait pairs. Canine characters stood out as strongly integrated, especially in the deciduous dentition. For homologous characters across dentitions (e.g., deciduous i1 shoveling and permanent I1 shoveling), ~70% of model comparisons yielded significant genetic correlations. Conclusions: Patterns of genetic correlation suggest a morphological canine module that spans the primary and secondary dentition. Results also point to the existence of a genetic mechanism conserving morphology across the diphyodont dental complex, such that paired deciduous and permanent traits are more strongly integrated than characters within individual tooth rows/teeth.
Keywords: Quantitative genetics; Dental morphology; Heritability; Pleiotropy; Dental development
Description: Available online 11 June 2021
Rights: © 2021 Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.archoralbio.2021.105168
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Appears in Collections:Dentistry publications

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