Please use this identifier to cite or link to this item:
Scopus Web of Science® Altmetric
Type: Journal article
Title: How does the early life environment influence the oral microbiome and determine oral health outcomes in childhood?
Author: Adler, C.J.
Cao, K.A.L.
Hughes, T.
Kumar, P.
Austin, C.
Citation: BioEssays, 2021; 43(9):2000314-1-2000314-13
Publisher: Wiley
Issue Date: 2021
ISSN: 0265-9247
Statement of
Christina Jane Adler, Kim-Anh Lê Cao, Toby Hughes, Piyush Kumar, Christine Austin
Abstract: The first 1000 days of life, from conception to 2 years, are a critical window for the influence of environmental exposures on the assembly of the oral microbiome, which is the precursor to dental caries (decay), one of the most prevalentmicrobially induced disorders worldwide. While it is known that the human microbiome is susceptible to environmental exposures, there is limited understanding of the impact of prenatal and early childhood exposures on the oral microbiome trajectory and oral health. A barrier has been the lack of technology to directly measure the foetal "exposome", which includes nutritional and toxic exposures crossing the placenta. Another barrier has been the lack of statistical methods to account for the high dimensional data generated by-omic assays. Through identifying which early life exposures influence the oral microbiome and modify oral health, these findings can be translated into interventions to reduce dental decay prevalence.
Keywords: dental caries; environment; exposures; -omics; Oral microbiome; postnatal; prenatal
Rights: ©2021 The Authors. BioEssays published byWiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
DOI: 10.1002/bies.202000314
Appears in Collections:Dentistry publications

Files in This Item:
File Description SizeFormat 
hdl_133211.pdfPublished version459.82 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.