Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/133414
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Type: Journal article
Title: The Association of Obstructive Sleep Apnea and Nocturnal Hypoxemia with Lipid Profiles in a Population-Based Study of Community-Dwelling Australian Men
Author: Guscoth, L.B.
Appleton, S.L.
Martin, S.A.
Adams, R.J.
Melaku, Y.A.
Wittert, G.A.
Citation: Nature and Science of Sleep, 2021; 13:1771-1782
Publisher: DovePress
Issue Date: 2021
ISSN: 1179-1608
1179-1608
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Responsibility: 
Layla B Guscoth, Sarah L Appleton, Sean A Martin, Robert J Adams, Yohannes A Melaku, Gary A Wittert
Abstract: Objective: To determine the association of obstructive sleep apnea and nocturnal hypoxemia with serum lipid profiles in unselected community-dwelling men. Methods: Cross-sectional data from participants of the Men Androgen Inflammation Lifestyle Environment and Stress (MAILES) study (n=753) who underwent full in-home polysomnography (Embletta X100) was used. Triglycerides, high- (HDL), low-density lipoprotein (LDL), and total cholesterol were assessed on a fasting morning blood sample. Multivariable linear regression analyses assessed associations between lipids and continuous measures of nocturnal hypoxemia (oxygen desaturation index (3%) (ODI), apnea–hypopnea index (AHI), and rapid eye movement sleep apnea–hypopnea index (REM-AHI)), adjusted for chronic conditions, risk behavior and sociodemographic factors. Sensitivity analyses examined the effect of lipid lowering therapies on reported estimates. Effect modification was examined through stratification by waist circumference groups. Results: In 753 participants with mean (SD) age of 60.8 (10.9) years and waist circumference: 99.3 (11.6) cm, the prevalence of OSA (AHI≥10) was 52.6%. Overall, no significant associations between OSA metrics and lipid measures were found. Similarly, sensitivity analysis excluding lipid lowering therapies showed no significant associations. In analysis stratified by waist circumference (<95cm, 95–100cm, >100cm), ODI (3%, unstandardized B: 0.027, 95% CI: 0.015–0.040), AHI (0.023, 0.012–0.033) and AHIREM (0.012, 0.001–0.022) were positively associated with serum triglycerides in participants with a normal waist circumference (<95cm). Conclusion: Obstructive sleep apnea metrics were positively associated with serum triglyceride levels in men with a normal waist circumference. Healthy weight individuals with OSA require clinical attention to improve cardiometabolic risk profiles.
Keywords: obstructive sleep apnea; triglycerides; hypoxemia; cohort studies; men; visceral obesity
Rights: © 2021 Guscoth et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms. php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
DOI: 10.2147/nss.s327478
Grant ID: http://purl.org/au-research/grants/nhmrc/627227
Appears in Collections:Medicine publications

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