Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/133898
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | 4CMenB vaccine and its role in preventing transmission and inducing herd immunity |
Author: | McMillan, M. Marshall, H.S. Richmond, P. |
Citation: | Expert Review of Vaccines, 2022; 21(1):103-114 |
Publisher: | Taylor & Francis |
Issue Date: | 2022 |
ISSN: | 1476-0584 1744-8395 |
Statement of Responsibility: | Mark McMillan, Helen S Marshall and Peter Richmond |
Abstract: | Introduction: Vaccination is the most effective method of protecting people from invasive meningococcal disease (IMD). Of all the capsular groups, B is the most common cause of invasive meningococcal disease in many parts of the world. Despite this, adolescent meningococcal B vaccine programs have not been implemented globally, partly due to the lack of evidence for herd immunity afforded by meningococcal B vaccines. Areas Covered: This review aims to synthesise the available evidence on recombinant 4CMenB vaccines' ability to reduce pharyngeal carriage and therefore provide indirect (herd) immunity against IMD. Expert Opinion: There is some evidence that the 4CMenB vaccine may induce cross-protection against non-B carriage of meningococci. However, the overall body of evidence does not support a clinically significant reduction in carriage of disease-associated or group B meningococci following 4CMenB vaccination. No additional cost-benefit from herd immunity effects should be included when modelling the cost-effectiveness of 4CMenB vaccine programs against group B IMD. 4CMenB immunisation programs should focus on direct (individual) protection for groups at greatest risk of meningococcal disease. Future meningococcal B and combination vaccines being developed should consider the impact of the vaccine on carriage as part of their clinical evaluation. |
Keywords: | Bexsero; carriage; herd protection; herd immunity; meningococcal; Neisseria meningitidis; 4cmenb |
Description: | Published online: 29 Nov 2021 |
Rights: | © 2021 Informa UK Limited, trading as Taylor & Francis Group |
DOI: | 10.1080/14760584.2022.2003708 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/GNT1155066 |
Published version: | http://dx.doi.org/10.1080/14760584.2022.2003708 |
Appears in Collections: | Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.