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Type: Journal article
Title: Candida auris susceptibility on surfaces coated with the antifungal drug caspofungin
Author: Lamont-Friedrich, S.J.
Kidd, S.E.
Giles, C.
Griesser, H.J.
Coad, B.R.
Citation: Medical Mycology, 2022; 60(1)
Publisher: Oxford University Press (OUP)
Issue Date: 2022
ISSN: 1369-3786
Statement of
Stephanie J. Lamont-Friedrich, Sarah E. Kidd, Carla Giles, Hans J. Griesser and Bryan R. Coad
Abstract: Candida auris is known to survive for weeks on solid material surfaces. Its longevity contributes to medical device contamination and spread through healthcare facilities. We fabricated antifungal surface coatings by coating plastic and glass surfaces with a thin polymer layer to which the antifungal drug caspofungin was covalently conjugated. Caspofungin-susceptible and -resistant C. auris strains were inhibited on these surfaces by 98.7 and 81.1%, respectively. Cell viability studies showed that this inhibition was fungicidal. Our findings indicate that C. auris strains can be killed on contact when exposed to caspofungin that is reformulated as a covalently-bound surface layer.
Keywords: Candida auris; mycoses; infection control; drug resistance; fungal susceptibility
Rights: ©The Author(s) 2021. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. All rights reserved. For permissions, please e-mail:
DOI: 10.1093/mmy/myab075
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Appears in Collections:Microbiology and Immunology publications

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