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Type: Journal article
Title: Slow-release oral morphine versus methadone: a crossover comparison of patient outcomes and acceptability as maintenance pharmacotherapies for opioid dependence
Author: Mitchell, T.
White, J.
Somogyi, A.
Bochner, F.
Citation: Addiction, 2004; 99(8):940-945
Publisher: Blackwell Publishing Ltd
Issue Date: 2004
ISSN: 0965-2140
Statement of
Timothy B. Mitchell, Jason M. White, Andrew A. Somogyi and Felix Bochner
Abstract: AIMS: To evaluate slow-release oral morphine (SROM) as an alternative maintenance pharmacotherapy to methadone for treatment of opioid dependence. DESIGN: Open-label crossover study. SETTING: Out-patient methadone maintenance programme. PARTICIPANTS: Eighteen methadone maintenance patients. INTERVENTION: Participants were transferred from methadone to SROM (once-daily Kapanol™) for approximately 6 weeks before resuming methadone maintenance. MEASUREMENTS: Patient outcomes were assessed (1) during the transition between medications (dose requirements, withdrawal severity) and (2) after at least 4 weeks on a stable dose of each drug (treatment preference, patient ratings of treatment efficacy and acceptability, drug use, health, depression and sleep). FINDINGS: Transfer from methadone to SROM was associated with relatively mild withdrawal for the first 5 days; the final mean SROM : methadone dose ratio was 4.6 : 1. Compared to methadone, SROM was associated with improved social functioning, weight loss, fewer and less troublesome side-effects, greater drug liking, reduced heroin craving, an enhanced sense of feeling ‘normal’ and similar outcomes for unsanctioned drug use, depression and health. The majority of subjects preferred SROM (78%) over methadone (22%). CONCLUSIONS: These findings provide justification for further evaluation of SROM as a maintenance pharmacotherapy for opioid dependence.
Keywords: Methadone; opiate dependence; sustained-release morphine; treatment outcomes
Description: The definitive version is available at
Rights: © 2004 Society for the Study of Addiction
RMID: 0020040761
DOI: 10.1111/j.1360-0443.2004.00764.x
Appears in Collections:Pharmacology publications

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