Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/14282
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Type: Journal article
Title: Effect of solid meal on gastric emptying of, and glycemic and cardiovascular responses to, liquid glucose in older subjects
Author: Berry, M.
Russo, A.
Wishart, J.
Tonkin, A.
Horowitz, M.
Jones, K.
Citation: American Journal of Physiology-Gastrointestinal and Liver Physiology, 2003; 284(4):G655-G662
Publisher: Amer Physiological Soc
Issue Date: 2003
ISSN: 0193-1857
1522-1547
Organisation: Medicine Learning and Teaching Unit
Statement of
Responsibility: 
Melanie K. Berry, Antonietta Russo, Judith M. Wishart, Anne Tonkin, Michael Horowitz, and Karen L. Jones
Abstract: Gastric emptying is a determinant of the postprandial glycemic and cardiovascular responses to oral carbohydrate. We evaluated the effects of a solid meal on gastric emptying and the glycemic and cardiovascular responses to oral glucose in healthy older subjects. Ten subjects aged 72.1 ± 1.9 yr were studied. Each subject had measurements of gastric emptying, blood glucose, serum insulin, blood pressure, and heart rate after ingestion of a 50-g glucose drink (300 ml) with (mixed meal) or without (liquid only) a solid meal (300 g ground beef). Gastric emptying of liquid was initially slightly more rapid (P < 0.05) after the mixed meal compared with liquid only at 5 min (92.0 ± 1.5 vs. 96.0 ± 1.3%) and much slower (P < 0.05) after 120 min. The time to peak blood glucose was less (39.0 ± 4.0 vs. 67.5 ± 10.3 min; P < 0.01) and blood glucose subsequently lower (P < 0.01) after the mixed meal. The increase in serum insulin was greater (P < 0.001) after the mixed meal. Blood pressure fell (P < 0.05) in the first 30 min, with no difference between the two meals. Increase in heart rate after both meals (P < 0.005), was greater (P < 0.05) after the mixed meal. The presence of a noncarbohydrate solid meal had discrepant effects on early and subsequent emptying of a nutrient liquid, which affects postprandial glycemia and increased heart rate.
Keywords: glycemic control; blood pressure; postprandial hypotension; blood glucose
Description: Published abstract used with permission of the copyright owner.
Rights: Copyright © 2005 by the American Physiological Society
RMID: 0020030292
DOI: 10.1152/ajpgi.00163.2002
Appears in Collections:Pharmacology publications

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