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|Title:||Effect of solid meal on gastric emptying of, and glycemic and cardiovascular responses to, liquid glucose in older subjects|
|Citation:||American Journal of Physiology-Gastrointestinal and Liver Physiology, 2003; 284(4):G655-G662|
|Publisher:||Amer Physiological Soc|
|Organisation:||Medicine Learning and Teaching Unit|
|Melanie K. Berry, Antonietta Russo, Judith M. Wishart, Anne Tonkin, Michael Horowitz, and Karen L. Jones|
|Abstract:||Gastric emptying is a determinant of the postprandial glycemic and cardiovascular responses to oral carbohydrate. We evaluated the effects of a solid meal on gastric emptying and the glycemic and cardiovascular responses to oral glucose in healthy older subjects. Ten subjects aged 72.1 ± 1.9 yr were studied. Each subject had measurements of gastric emptying, blood glucose, serum insulin, blood pressure, and heart rate after ingestion of a 50-g glucose drink (300 ml) with (mixed meal) or without (liquid only) a solid meal (300 g ground beef). Gastric emptying of liquid was initially slightly more rapid (P < 0.05) after the mixed meal compared with liquid only at 5 min (92.0 ± 1.5 vs. 96.0 ± 1.3%) and much slower (P < 0.05) after 120 min. The time to peak blood glucose was less (39.0 ± 4.0 vs. 67.5 ± 10.3 min; P < 0.01) and blood glucose subsequently lower (P < 0.01) after the mixed meal. The increase in serum insulin was greater (P < 0.001) after the mixed meal. Blood pressure fell (P < 0.05) in the first 30 min, with no difference between the two meals. Increase in heart rate after both meals (P < 0.005), was greater (P < 0.05) after the mixed meal. The presence of a noncarbohydrate solid meal had discrepant effects on early and subsequent emptying of a nutrient liquid, which affects postprandial glycemia and increased heart rate.|
|Keywords:||glycemic control; blood pressure; postprandial hypotension; blood glucose|
|Description:||Published abstract used with permission of the copyright owner.|
|Rights:||Copyright © 2005 by the American Physiological Society|
|Appears in Collections:||Pharmacology publications|
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