Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/14282
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dc.contributor.authorBerry, M.-
dc.contributor.authorRusso, A.-
dc.contributor.authorWishart, J.-
dc.contributor.authorTonkin, A.-
dc.contributor.authorHorowitz, M.-
dc.contributor.authorJones, K.-
dc.date.issued2003-
dc.identifier.citationAmerican Journal of Physiology: Gastrointestinal and Liver Physiology, 2003; 284(4):G655-G662-
dc.identifier.issn0193-1857-
dc.identifier.issn1522-1547-
dc.identifier.urihttp://hdl.handle.net/2440/14282-
dc.descriptionPublished abstract used with permission of the copyright owner.-
dc.description.abstractGastric emptying is a determinant of the postprandial glycemic and cardiovascular responses to oral carbohydrate. We evaluated the effects of a solid meal on gastric emptying and the glycemic and cardiovascular responses to oral glucose in healthy older subjects. Ten subjects aged 72.1 ± 1.9 yr were studied. Each subject had measurements of gastric emptying, blood glucose, serum insulin, blood pressure, and heart rate after ingestion of a 50-g glucose drink (300 ml) with (mixed meal) or without (liquid only) a solid meal (300 g ground beef). Gastric emptying of liquid was initially slightly more rapid (P < 0.05) after the mixed meal compared with liquid only at 5 min (92.0 ± 1.5 vs. 96.0 ± 1.3%) and much slower (P < 0.05) after 120 min. The time to peak blood glucose was less (39.0 ± 4.0 vs. 67.5 ± 10.3 min; P < 0.01) and blood glucose subsequently lower (P < 0.01) after the mixed meal. The increase in serum insulin was greater (P < 0.001) after the mixed meal. Blood pressure fell (P < 0.05) in the first 30 min, with no difference between the two meals. Increase in heart rate after both meals (P < 0.005), was greater (P < 0.05) after the mixed meal. The presence of a noncarbohydrate solid meal had discrepant effects on early and subsequent emptying of a nutrient liquid, which affects postprandial glycemia and increased heart rate.-
dc.description.statementofresponsibilityMelanie K. Berry, Antonietta Russo, Judith M. Wishart, Anne Tonkin, Michael Horowitz, and Karen L. Jones-
dc.language.isoen-
dc.publisherAmer Physiological Soc-
dc.rightsCopyright © 2005 by the American Physiological Society-
dc.subjectglycemic control-
dc.subjectblood pressure-
dc.subjectpostprandial hypotension-
dc.subjectblood glucose-
dc.titleEffect of solid meal on gastric emptying of, and glycemic and cardiovascular responses to, liquid glucose in older subjects-
dc.typeJournal article-
dc.contributor.organisationMedicine Learning and Teaching Unit-
dc.identifier.doi10.1152/ajpgi.00163.2002-
pubs.publication-statusPublished-
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]-
dc.identifier.orcidJones, K. [0000-0002-1155-5816]-
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