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Type: Journal article
Title: Assembly of PRR-containing receptors on scaffolds: a model for imidazoline I1-receptor action
Author: Musgrave, I.
Dehle, F.
Piletz, J.
Citation: Annals of the New York Academy of Sciences, 2003; 1009(1):413-418
Publisher: New York Acad Sciences
Issue Date: 2003
ISSN: 0077-8923
Abstract: IRAS, a putative clone of the I₁-imidazoline receptor, possesses a proline-rich region (PRR) motif, which might interact with SH3 regions on tyrosine kinases, and an integrin-binding motif. Receptors with a PRR motif can generally assemble onto multi-element signaling complexes (eg., the b₃-receptor on the EGF receptor) and thereby modulate signal transduction. Integrins serve as scaffolds for multi-element signaling complexes, similar to that assembled with the EGF receptor. It is therefore possible that IRAS signals through a complex with other receptors.
Keywords: imidazoline receptors; signal transduction; integrin; scaffold; tyrosine kinase; Nischarin
Description: The definitive version is available at
RMID: 0020032330
DOI: 10.1196/annals.1304.055
Published version:
Appears in Collections:Pharmacology publications

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