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|Title:||Assembly of PRR-containing receptors on scaffolds: a model for imidazoline I1-receptor action|
|Citation:||Annals of the New York Academy of Sciences, 2003; 1009(1):413-418|
|Publisher:||New York Acad Sciences|
|Abstract:||IRAS, a putative clone of the I₁-imidazoline receptor, possesses a proline-rich region (PRR) motif, which might interact with SH3 regions on tyrosine kinases, and an integrin-binding motif. Receptors with a PRR motif can generally assemble onto multi-element signaling complexes (eg., the b₃-receptor on the EGF receptor) and thereby modulate signal transduction. Integrins serve as scaffolds for multi-element signaling complexes, similar to that assembled with the EGF receptor. It is therefore possible that IRAS signals through a complex with other receptors.|
|Keywords:||imidazoline receptors; signal transduction; integrin; scaffold; tyrosine kinase; Nischarin|
|Description:||The definitive version is available at www.blackwell-synergy.com|
|Appears in Collections:||Pharmacology publications|
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