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https://hdl.handle.net/2440/14288
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Type: | Journal article |
Title: | Assembly of PRR-containing receptors on scaffolds: a model for imidazoline I1-receptor action |
Author: | Musgrave, I. Dehle, F. Piletz, J. |
Citation: | Annals of the New York Academy of Sciences, 2003; 1009(1):413-418 |
Publisher: | New York Acad Sciences |
Issue Date: | 2003 |
ISSN: | 0077-8923 1749-6632 |
Editor: | Piletz, J.E. Regunathan, S. Ernsberger, P. |
Abstract: | IRAS, a putative clone of the I₁-imidazoline receptor, possesses a proline-rich region (PRR) motif, which might interact with SH3 regions on tyrosine kinases, and an integrin-binding motif. Receptors with a PRR motif can generally assemble onto multi-element signaling complexes (eg., the b₃-receptor on the EGF receptor) and thereby modulate signal transduction. Integrins serve as scaffolds for multi-element signaling complexes, similar to that assembled with the EGF receptor. It is therefore possible that IRAS signals through a complex with other receptors. |
Keywords: | imidazoline receptors signal transduction integrin scaffold tyrosine kinase Nischarin |
Description: | The definitive version is available at www.blackwell-synergy.com |
DOI: | 10.1196/annals.1304.055 |
Published version: | http://www.annalsnyas.org/cgi/content/abstract/1009/1/413 |
Appears in Collections: | Aurora harvest 7 Pharmacology publications |
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