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Type: Journal article
Title: Lack of effect of gender and oral contraceptive steroids on the pharmacokinetics of (R)-ibuprofen in human.
Author: Knights, K.
McLean, C.
Tonkin, A.
Miners, J.
Citation: British Journal of Clinical Pharmacology, 1995; 40(2):153-156
Publisher: Blackwell Scientific
Issue Date: 1995
ISSN: 0306-5251
Statement of
Knights, Km ; Mclean, Cf ; Tonkin, Al ; Miners, Jo
Abstract: The effects of gender and oral contraceptive steroids on the pharmacokinetics of (R)-ibuprofen were studied in groups of healthy adult males, females and oral contraceptive steroid (OCS) using females. The values of AUC, CLpo, t1/2 and Vss, app did not differ significantly between the groups. Similarly, the percentage unbound of (R)-ibuprofen in pooled plasma from the three groups was not statistically different. Since chiral inversion is the major determinant of (R)-ibuprofen clearance in humans, it may be inferred from these data that gender and OCS have little or no effect on conversion of (R)-ibuprofen to the pharmacologically active S-enantiomer. Moreover, it is unlikely that hormonal factors influence the activity of the human hepatic long-chain fatty-acid:CoA ligase, the enzyme mediating the rate limiting step of (R)-ibuprofen inversion.
Keywords: Humans; Ibuprofen; Contraceptives, Oral, Hormonal; Anti-Inflammatory Agents, Non-Steroidal; Administration, Oral; Analysis of Variance; Sex Factors; Stereoisomerism; Adolescent; Adult; Female; Male
RMID: 0030003438
DOI: 10.1111/j.1365-2125.1995.tb05769.x
Appears in Collections:Pharmacology publications

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