Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/14362
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dc.contributor.authorTaverner, D.en
dc.contributor.authorMarley, J.en
dc.contributor.authorTonkin, A.en
dc.date.issued1999en
dc.identifier.citationClinical and Experimental Pharmacology and Physiology, 1999; 26(11):909-913en
dc.identifier.issn0305-1870en
dc.identifier.issn1440-1681en
dc.identifier.urihttp://hdl.handle.net/2440/14362-
dc.description.abstract1. The aim of the present study was to compare the efficacy of nifedipine Oros and felodipine extended release (ER) in controlling 24 h ambulatory blood pressures (ABP) in hypertensive patients. 2. The study was a randomized cross-over design with a 2 week open placebo run-in phase and two observer-blind treatment periods. 3. Subjects were males and females, aged between 18 and 65 years, suffering from mild to moderate essential hypertension with a sitting mean diastolic blood pressure (DBP) within the range of 95-114 mmHg. Twenty-three subjects were randomized to treatment; 15 patients completed the study. 4. Treatment intervention was 2 weeks of placebo followed by either 30 mg nifedipine OROS once daily or 5 mg felodipine ER once daily for 6 weeks, which was titrated up to 60 mg nifedipine OROS daily or 10 mg felodipine ER daily after 2 weeks of treatment on the lower doses if the DBP was > 90 mmHg. The main outcome measure was 24 h ABP after 6 weeks of active treatment, evaluated by an independent observer blinded as to treatment allocation. 5. Compared with placebo, mean (+/- SD) 24 h DBP was reduced by 6.2 +/- 6.8 and 5.2 +/- 5.1 mmHg after nifedipine and felodipine, respectively. The 24 h mean systolic blood pressure (SBP) fell by 11.8 +/- 10.9 and 10.1 +/- 8.2 mmHg for nifedipine and felodipine, respectively, compared with placebo. There were no significant differences between the two active treatments in the reduction of DBP or SBP during the 24 h period, daytime or night-time. 6. Similar antihypertensive effects are achieved with nifedipine Oros and felodipine ER when doses are individually titrated, with no significant differences between the two treatments.en
dc.language.isoenen
dc.publisherBLACKWELL SCIENCE ASIAen
dc.subjectambulatory blood pressure; controlled trial; cross-over; felodipine; nifedipine; Oros®; randomizeden
dc.titleCrossover comparison of nifedipine OROS(R) and felodipine extended release with blind 24 H ambulatory blood pressure assessmentsen
dc.typeJournal articleen
dc.identifier.rmid0030003430en
dc.identifier.doi10.1046/j.1440-1681.1999.03164.xen
dc.identifier.pubid67436-
pubs.library.collectionPharmacology publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
Appears in Collections:Pharmacology publications

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