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Type: Journal article
Title: Genetic aspects of dental disorders
Author: Townsend, G.
Aldred, M.
Bartold, P.
Citation: Australian Dental Journal, 1998; 43(4):269-286
Publisher: Australian Dental Association
Issue Date: 1998
ISSN: 0045-0421
Statement of
Grant C. Townsend, Michael J. Aldred and P. Mark Bartold
Abstract: This paper reviews past and present applications of quantitative and molecular genetics to dental disorders. Examples are given relating to craniofacial development (including malocclusion), oral supporting tissues (including periodontal diseases) and dental hard tissues (including defects of enamel and dentine as well as dental caries). Future developments and applications to clinical dentistry are discussed. Early investigations confirmed genetic bases to dental caries, periodontal diseases and malocclusion, but research findings have had little impact on clinical practice. The complex multifactorial aetiologies of these conditions, together with methodological problems, have limited progress until recently. Present studies are clarifying previously unrecognized genetic and phenotypic heterogeneities and attempting to unravel the complex interactions between genes and environment by applying new statistical modelling approaches to twin and family data. linkage studies using highly polymorphic DNA markers are providing a means of locating candidate genes, including quantitative trait loci (QTL). In future, as knowledge increases: it should be possible to implement preventive strategies for those genetically-predisposed individuals who are identified-predisposed individuals who are identified to be at risk.
Keywords: Heredity
periodontal diseases
gene mapping
enamel defects
dentine defects
Description: The document attached has been archived with permission from the Australian Dental Association. An external link to the publisher’s copy is included.
DOI: 10.1111/j.1834-7819.1998.tb00176.x
Published version:
Appears in Collections:Aurora harvest 2
Dentistry publications

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