Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/14390
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Type: Journal article
Title: Guar attenuates fall in postprandial blood pressure and slows gastric emptying of oral glucose in type 2 diabetes
Author: Russo, A.
Stevens, J.
Wilson, T.
Wells, F.
Tonkin, A.
Horowitz, M.
Jones, K.
Citation: Digestive Diseases and Sciences, 2003; 48(7):1221-1229
Publisher: Kluwer Academic/Plenum Publ
Issue Date: 2003
ISSN: 0163-2116
1573-2568
Organisation: Medicine Learning and Teaching Unit
Statement of
Responsibility: 
Antonietta Russo, Julie E. Stevens, Toni Wilson, Fiona Wells, Anne Tonkin, Michael Horowitz and Karen L. Jones
Abstract: Postprandial hypotension occurs frequently in diabetes; the fall in blood pressure is greatest after ingestion of carbohydrate, particularly glucose and, in type 2 diabetes, is related to the rate of gastric emptying. The aim of this study was to determine whether slowing of gastric emptying by guar gum reduces the fall in blood pressure after oral glucose in patients with type 2 diabetes. Eleven type 2 patients managed by diet alone, age 61.9 ┬▒ 1.3 years, had measurements of gastric emptying, blood pressure, blood glucose, and serum insulin on two occasions after ingestion of 300 ml water containing 50 g glucose, with or without 9 g guar gum. The magnitude of the fall in blood pressure was less (P < 0.05) and gastric emptying slower (P < 0.05) after guar. Blood glucose (P < 0.05) and serum insulin (P < 0.01) concentrations were lower after guar. The magnitude of the fall in systolic blood pressure was related to gastric emptying of glucose at 30 min on the control day (r = 0.67, P < 0.05). We conclude that guar gum attenuates the fall in blood pressure after oral glucose in patients with type 2 diabetes mellitus, presumably by slowing glucose absorption.
Keywords: postprandial hypotension; gastric emptying; small intestinal absorption; blood glucose; guar gum; insulin
Description: The original publication can be found at www.springerlink.com
RMID: 0020030144
DOI: 10.1023/A:1024182403984
Appears in Collections:Pharmacology publications

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