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Type: Journal article
Title: Combined cardiac effects of cocaine and the anabolic steroid, nandralone, in the rat
Author: Phillis, B.
Irvine, R.
Kennedy, J.
Citation: European Journal of Pharmacology, 2000; 398(2):263-272
Publisher: Elsevier Science BV
Issue Date: 2000
ISSN: 0014-2999
Abstract: Despite reports of an increase in the incidence of simultaneous cocaine and anabolic steroid abuse, potential adverse interactions between these two drugs on the cardiovascular system are largely unquantified. Cocaine has been reported to induce coronary vasoconstriction, cardiac arrhythmias and conduction delays. Anabolic steroids have been associated with cardiac hypertrophy and hypertension. Utilising both in vivo (radiotelemetry) and in vitro (isolated Langendorff-perfused heart) techniques, our aim was to determine whether anabolic steroids cause cardiac hypertrophy and alter cardiac function, and consequently alter the response of the heart to cocaine. It was found that 15 days of treatment of rats with nandrolone decanoate (20 mg/kg, s.c.) was not sufficient to cause hypertrophy, alter cardiac function or the spread of electrical activity through the heart. However, nandrolone pretreatment was found to significantly potentiate the heart rate response to cocaine (45 mg/kg, i.p.) in vivo. This study indicates that nandrolone significantly elevates the heart rate response to high dose cocaine without changing heart morphology. The mechanism of this interaction remains uncertain.
Keywords: Cardiovascular System; Heart; Animals; Rats; Rats, Wistar; Body Weight; Cocaine; Nandrolone; Anabolic Agents; Electrocardiography; Organ Size; Area Under Curve; Perfusion; Motor Activity; Temperature; Heart Rate; Coronary Circulation; Dose-Response Relationship, Drug; Male; Cardiovascular Physiological Phenomena
RMID: 0001000124
DOI: 10.1016/S0014-2999(00)00294-6
Appears in Collections:Pharmacology publications

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