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Type: Journal article
Title: Guar gum reduces postprandial hypotension in older people
Author: Jones, K.
MacIntosh, C.
Su, Y.
Wells, F.
Chapman, I.
Tonkin, A.
Horowitz, M.
Citation: Journal of the American Geriatrics Society, 2001; 49(2):162-167
Publisher: Blackwell Science Inc.
Issue Date: 2001
ISSN: 0002-8614
Statement of
Karen L. Jones, Caroline MacIntosh, Yu-Chung Su, Fiona Wells, Ian M. Chapman, Anne Tonkin, Michael Horowitz
Abstract: OBJECTIVE:To determine whether slowing of gastric emptying and glucose absorption with guar gum would reduce the fall in blood pressure after an oral glucose load in older subjects. DESIGN:A randomized, experimental, cross-over study. SETTING:Department of Nuclear Medicine, Royal Adelaide Hospital, Adelaide, SA, Australia. PARTICIPANTS:Ten healthy subjects, age 67 to 78. MEASUREMENTS:Simultaneous measurements of gastric emptying, blood pressure, blood glucose, serum insulin, and oral glucose absorption (3-O-methyl-D-glucose [3-OMG]) on two occasions after ingestion of 300 mL water containing 50 g glucose and 30 mL lemon juice, 3 g 3-OMG labeled with 99mTc-sulphur colloid; with or without 9 g guar gum. Blood pressure and gastric emptying were monitored for 180 minutes. RESULTS:The magnitude of the falls in systolic (P = .02), diastolic (P < .05), and mean arterial (P = .05) blood pressure were less, and gastric emptying slower (P < .05), after guar. Blood glucose, insulin, and 3-OMG concentrations were reduced (P < .001 for all) by guar. 3-OMG concentrations were inversely related to the intragastric retention of glucose (r = -0.72, P = .02) and blood pressure was inversely related to 3-OMG (r = -0.64, P < .05) after the drink without guar. The blood glucose concentration was related to 3-OMG (r > 0.64, P < .05). CONCLUSION:Guar gum reduces the magnitude of the fall in blood pressure after oral glucose. Slowing of gastric emptying and glucose absorption may represent a novel approach to the treatment of postprandial hypotension.
Keywords: postprandial hypotension; gastric emptying; small intestinal absorption; 3-OMG; older; blood glucose; guar gum
Description: The definitive version is available at
RMID: 0020011086
DOI: 10.1046/j.1532-5415.2001.49037.x
Appears in Collections:Pharmacology publications

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