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Type: Journal article
Title: The renin-angiotensin system and nociception in the spontaneously hypertensive rat
Author: Irvine, R.
White, J.
Head, R.
Citation: Life Sciences, 1995; 56(13):1073-1078
Publisher: Pergamon Press
Issue Date: 1995
ISSN: 0024-3205
Statement of
Rodney J Irvine, Jason M White and Richard J Head
Abstract: This study investigated the effects of captopril, hydralazine and losartan on the locomotor activity, tailflick and hot plate latencies in spontaneously hypertensive rats (SHR) and their genetic controls the Wistar-Kyoto rat (WKY). The increased hot plate latencies normally exhibited by the spontaneously hypertensive rat were reduced or abolished by captopril ( 95 mg/kg/day p.o.) and losartan (18 mg/kg/day p.o.) treatment, but were unaffected by hydralazine (19 mg/kg/day p.o.). There were no observable effects of any of the drugs on tailflick latencies or locomotor activity. The results highlight a potential role for angiotensin II in analgesia that is independent of blood pressure change.
Keywords: spontaneously hypertensive rat
Rights: Copyright © 1995 Elsevier Science Ltd
DOI: 10.1016/0024-3205(95)00043-6
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Pharmacology publications

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