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|Title:||The renin-angiotensin system and nociception in the spontaneously hypertensive rat|
|Citation:||Life Sciences, 1995; 56(13):1073-1078|
|Rodney J Irvine, Jason M White and Richard J Head|
|Abstract:||This study investigated the effects of captopril, hydralazine and losartan on the locomotor activity, tailflick and hot plate latencies in spontaneously hypertensive rats (SHR) and their genetic controls the Wistar-Kyoto rat (WKY). The increased hot plate latencies normally exhibited by the spontaneously hypertensive rat were reduced or abolished by captopril ( 95 mg/kg/day p.o.) and losartan (18 mg/kg/day p.o.) treatment, but were unaffected by hydralazine (19 mg/kg/day p.o.). There were no observable effects of any of the drugs on tailflick latencies or locomotor activity. The results highlight a potential role for angiotensin II in analgesia that is independent of blood pressure change.|
|Keywords:||spontaneously hypertensive rat; analgesia; captopril; losartan|
|Rights:||Copyright © 1995 Elsevier Science Ltd|
|Appears in Collections:||Pharmacology publications|
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