Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/14498
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dc.contributor.authorIrvine, R.-
dc.contributor.authorWhite, J.-
dc.contributor.authorHead, R.-
dc.date.issued1995-
dc.identifier.citationLife Sciences, 1995; 56(13):1073-1078-
dc.identifier.issn0024-3205-
dc.identifier.issn1879-0631-
dc.identifier.urihttp://hdl.handle.net/2440/14498-
dc.description.abstractThis study investigated the effects of captopril, hydralazine and losartan on the locomotor activity, tailflick and hot plate latencies in spontaneously hypertensive rats (SHR) and their genetic controls the Wistar-Kyoto rat (WKY). The increased hot plate latencies normally exhibited by the spontaneously hypertensive rat were reduced or abolished by captopril ( 95 mg/kg/day p.o.) and losartan (18 mg/kg/day p.o.) treatment, but were unaffected by hydralazine (19 mg/kg/day p.o.). There were no observable effects of any of the drugs on tailflick latencies or locomotor activity. The results highlight a potential role for angiotensin II in analgesia that is independent of blood pressure change.-
dc.description.statementofresponsibilityRodney J Irvine, Jason M White and Richard J Head-
dc.language.isoen-
dc.publisherPergamon Press-
dc.rightsCopyright © 1995 Elsevier Science Ltd-
dc.source.urihttp://dx.doi.org/10.1016/0024-3205(95)00043-6-
dc.subjectspontaneously hypertensive rat-
dc.subjectanalgesia-
dc.subjectcaptopril-
dc.subjectlosartan-
dc.titleThe renin-angiotensin system and nociception in the spontaneously hypertensive rat-
dc.typeJournal article-
dc.identifier.doi10.1016/0024-3205(95)00043-6-
pubs.publication-statusPublished-
dc.identifier.orcidHead, R. [0000-0002-1196-0926]-
Appears in Collections:Aurora harvest 7
Pharmacology publications

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