Please use this identifier to cite or link to this item:
Scopus Web of Science® Altmetric
Type: Journal article
Title: Attenuation of morphine withdrawal signs by the GABAB receptor agonist baclofen
Author: Bexis, S.
Ong, J.
White, J.
Citation: Life Sciences, 2001; 70(4):395-401
Publisher: Pergamon-Elsevier Science Ltd
Issue Date: 2001
ISSN: 0024-3205
Statement of
Sotiria Bexis, Jennifer Ong and Jason White
Abstract: Abstract The present study examined the effect of the γ-aminobutyric acidB (GABAB) receptor agonist, baclofen on naloxone-induced withdrawal signs in morphine-dependent rats and modification by the antagonist, 3-aminopropyl-cyclohexylmethylphosphinic acid (CGP 46381). Morphine was administered via mini-osmotic pumps for 7 days to induce physical dependence. Baclofen (20 mg kg−1) decreased stereotyped head movements, chewing, chatter, ptosis and body weight loss, induced by naloxone (10 mg kg−1) in morphine-dependent rats. CGP 46381 (20 mg kg−1) reversed the effects exerted by baclofen on stereotyped head movements, ptosis, and weight loss and partially reversed the effect of baclofen on chewing. It can be concluded that baclofen has some potential in the treatment of opioid withdrawal and that GABAB receptors may be implicated in such a withdrawal.
Keywords: Baclofen
Morphine withdrawal
CGP 46381
DOI: 10.1016/S0024-3205(01)01485-0
Description (link):
Published version:
Appears in Collections:Aurora harvest 7
Pharmacology publications

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.